Jishu Xu
Overview
Explore the profile of Jishu Xu including associated specialties, affiliations and a list of published articles.
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40
Citations
2225
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Recent Articles
1.
Laurie S, Steyaert W, de Boer E, Polavarapu K, Schuermans N, Sommer A, et al.
Nat Med
. 2025 Jan;
31(2):478-489.
PMID: 39825153
Genetic diagnosis of rare diseases requires accurate identification and interpretation of genomic variants. Clinical and molecular scientists from 37 expert centers across Europe created the Solve-Rare Diseases Consortium (Solve-RD) resource,...
2.
Ng B, Avey D, de Paiva Lopes K, Fujita M, Vialle R, Vyas H, et al.
bioRxiv
. 2024 Nov;
PMID: 39554066
Long non-coding RNAs (lncRNAs) are critical regulators of physiological and pathological processes, with their dysregulation increasingly implicated in aging and Alzheimer's disease (AD). Using spatial transcriptomics, we analyzed 78 postmortem...
3.
Tasaki S, Avey D, Kearns N, Iatrou A, Yu C, Tissera S, et al.
bioRxiv
. 2024 Nov;
PMID: 39484606
The gene signatures of Alzheimer's Disease (AD) brains reflect an output of a complex interplay of genetic, epigenetic, epi-transcriptomic, and post-transcriptional regulations. To identify the most significant factor that shapes...
4.
Avey D, Ng B, Vialle R, Kearns N, de Paiva Lopes K, Iatrou A, et al.
bioRxiv
. 2024 Sep;
PMID: 39314329
Amyloid-beta (Aβ) plaques and surrounding glial activation are prominent histopathological hallmarks of Alzheimer's Disease (AD). However, it is unclear how Aβ plaques interact with surrounding glial cells in the human...
5.
Parrish R, Buchman A, Tasaki S, Wang Y, Avey D, Xu J, et al.
Nat Commun
. 2024 Aug;
15(1):6646.
PMID: 39103319
Multiple reference panels of a given tissue or multiple tissues often exist, and multiple regression methods could be used for training gene expression imputation models for transcriptome-wide association studies (TWAS)....
6.
Steyaert W, Sagath L, Demidov G, Yepez V, Esteve-Codina A, Gagneur J, et al.
medRxiv
. 2024 May;
PMID: 38746462
Solve-RD is a pan-European rare disease (RD) research program that aims to identify disease-causing genetic variants in previously undiagnosed RD families. We utilised 10-fold coverage HiFi long-read sequencing (LRS) for...
7.
Xu J, Horner M, Nagel M, Perhat P, Korneck M, Noss M, et al.
bioRxiv
. 2024 Apr;
PMID: 38585749
Neuronal function and pathology are deeply influenced by the distinct molecular profiles of the axon and soma. Traditional studies have often overlooked these differences due to the technical challenges of...
8.
Kearns N, Iatrou A, Flood D, Tissera S, Mullaney Z, Xu J, et al.
Nat Commun
. 2023 Nov;
14(1):7036.
PMID: 37923721
Emerging evidence shows that the meninges conduct essential immune surveillance and immune defense at the brain border, and the dysfunction of meningeal immunity contributes to aging and neurodegeneration. However, no...
9.
Tang S, Buchman A, Wang Y, Avey D, Xu J, Tasaki S, et al.
Sci Rep
. 2023 Oct;
13(1):16570.
PMID: 37789141
Differential gene expression (DGE) analysis has been widely employed to identify genes expressed differentially with respect to a trait of interest using RNA sequencing (RNA-Seq) data. Recent RNA-Seq data with...
10.
Parrish R, Buchman A, Tasaki S, Wang Y, Avey D, Xu J, et al.
medRxiv
. 2023 Jul;
PMID: 37425698
Multiple reference panels of a given tissue or multiple tissues often exist, and multiple regression methods could be used for training gene expression imputation models for TWAS. To leverage expression...