Jimmy D Ballard
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Explore the profile of Jimmy D Ballard including associated specialties, affiliations and a list of published articles.
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79
Citations
1658
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Recent Articles
21.
Lavey N, Shadid T, Ballard J, Duerfeldt A
ACS Infect Dis
. 2018 Nov;
5(1):79-89.
PMID: 30411608
Caseinolytic protease P (ClpP) has emerged as a promising new target for antibacterial development. While ClpPs from single isoform expressing bacteria have been studied in detail, the function and regulation...
22.
23.
Larabee J, Hauck G, Ballard J
J Biol Chem
. 2017 Dec;
293(5):1810-1819.
PMID: 29247010
TcdB (2366 amino acid residues) is an intracellular bacterial toxin that binds to cells and enters the cytosol where it glucosylates small GTPases. In the current study, we examined a...
24.
Hunt J, Larabee J, Ballard J
mSphere
. 2017 Aug;
2(4).
PMID: 28776043
TcdB2 enters cells with a higher efficiency than TcdB1 and exhibits an overall higher level of toxicity. However, the TcdB2-specific sequences that account for more efficient cell entry have not...
25.
Larabee J, Bland S, Hunt J, Ballard J
mBio
. 2017 May;
8(3).
PMID: 28512094
infection (CDI) is a major cause of hospital-associated, antibiotic-induced diarrhea, which is largely mediated by the production of two large multidomain clostridial toxins, TcdA and TcdB. Both toxins coordinate the...
26.
Rampuria P, Lang G, Devera T, Gilmore C, Ballard J, Lang M
J Leukoc Biol
. 2016 Aug;
101(2):567-576.
PMID: 27566831
Activation of iNKT cells with the CD1d-binding glycolipid adjuvant α-galactosylceramide (α-GC) enhances humoral immunity specific for coadministered T-dependent Ag. However, the relationship between the iNKT cell and the classic T...
27.
Devera T, Lang G, Lanis J, Rampuria P, Gilmore C, James J, et al.
Infect Immun
. 2015 Oct;
84(1):194-204.
PMID: 26502913
Secreted toxin B (TcdB) substantially contributes to the pathology observed during Clostridium difficile infection. To be successfully incorporated into a vaccine, TcdB-based immunogens must stimulate the production of neutralizing antibody...
28.
Devera T, Prusator D, Joshi S, Ballard J, Lang M
Toxins (Basel)
. 2015 Jun;
7(7):2371-84.
PMID: 26120785
Protective immunity against anthrax is inferred from measurement of vaccine antigen-specific neutralizing antibody titers in serum samples. In animal models, in vivo challenges with toxin and/or spores can also be...
29.
Larabee J, Krumholz A, Hunt J, Lanis J, Ballard J
J Biol Chem
. 2015 Jan;
290(11):6975-85.
PMID: 25614625
The sequence, activity, and antigenicity of TcdB varies between different strains of Clostridium difficile. As a result, ribotype-specific forms of TcdB exhibit different toxicities and are not strongly cross-neutralized. Using...
30.
Hunt J, Ballard J
Microbiol Mol Biol Rev
. 2013 Dec;
77(4):567-81.
PMID: 24296572
Clostridium difficile is a Gram-positive, spore-forming organism which infects and colonizes the large intestine, produces potent toxins, triggers inflammation, and causes significant systemic complications. Treating C. difficile infection (CDI) has...