Jill P Mesirov
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Explore the profile of Jill P Mesirov including associated specialties, affiliations and a list of published articles.
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128
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82678
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Recent Articles
11.
Liefeld T, Huang E, Wenzel A, Yoshimoto K, Sharma A, Sicklick J, et al.
bioRxiv
. 2023 Jul;
PMID: 37398372
Non-negative Matrix Factorization (NME) is an algorithm that can reduce high dimensional datasets of tens of thousands of genes to a handful of metagenes which are biologically easier to interpret....
12.
Wu V, Yung B, Faraji F, Saddawi-Konefka R, Wang Z, Wenzel A, et al.
Nat Immunol
. 2023 Jun;
24(8):1318-1330.
PMID: 37308665
Immune checkpoint blockade (ICB) targeting PD-1 and CTLA-4 has revolutionized cancer treatment. However, many cancers do not respond to ICB, prompting the search for additional strategies to achieve durable responses....
13.
Pagadala M, Sears T, Wu V, Perez-Guijarro E, Kim H, Castro A, et al.
Nat Commun
. 2023 May;
14(1):2744.
PMID: 37173324
With the continued promise of immunotherapy for treating cancer, understanding how host genetics contributes to the tumor immune microenvironment (TIME) is essential to tailoring cancer screening and treatment strategies. Here,...
14.
Okonechnikov K, Camgoz A, Chapman O, Wani S, Park D, Hubner J, et al.
Nat Commun
. 2023 Apr;
14(1):2300.
PMID: 37085539
Ependymoma is a tumor of the brain or spinal cord. The two most common and aggressive molecular groups of ependymoma are the supratentorial ZFTA-fusion associated and the posterior fossa ependymoma...
15.
Reich M, Tabor T, Liefeld J, Joshi J, Kim F, Thorvaldsdottir H, et al.
bioRxiv
. 2023 Apr;
PMID: 37066251
We present Genomics to Notebook (g2nb), an environment that combines the JupyterLab notebook system with widely-used bioinformatics platforms. Galaxy, GenePattern, and the JavaScript versions of IGV and Cytoscape are currently...
16.
Robinson J, Thorvaldsdottir H, Turner D, Mesirov J
Bioinformatics
. 2022 Dec;
39(1).
PMID: 36562559
Summary: igv.js is an embeddable JavaScript implementation of the Integrative Genomics Viewer (IGV). It can be easily dropped into any web page with a single line of code and has...
17.
Leskoske K, Garcia-Mansfield K, Sharma R, Krishnan A, Rusert J, Mesirov J, et al.
J Proteome Res
. 2022 Aug;
21(9):2124-2136.
PMID: 35977718
Medulloblastoma (MB) is the most common malignant pediatric brain tumor. MB is classified into four primary molecular subgroups: wingless (WNT), sonic hedgehog (SHH), Group 3 (G3), and Group 4 (G4),...
18.
Saddawi-Konefka R, OFarrell A, Faraji F, Clubb L, Allevato M, Jensen S, et al.
Nat Commun
. 2022 Jul;
13(1):4298.
PMID: 35879302
Despite the promise of immune checkpoint inhibition (ICI), therapeutic responses remain limited. This raises the possibility that standard of care treatments delivered in concert may compromise the tumor response. To...
19.
Wenzel A, Champa D, Venkatesh H, Sun S, Tsai C, Mesirov J, et al.
NPJ Syst Biol Appl
. 2022 Jun;
8(1):20.
PMID: 35715421
The molecular underpinnings of acquired resistance to carboplatin are poorly understood and often inconsistent between in vitro modeling studies. After sequential treatment cycles, multiple isogenic clones reached similar levels of...
20.
Richelle A, Kellman B, Wenzel A, Chiang A, Reagan T, Gutierrez J, et al.
Cell Rep Methods
. 2021 Nov;
1(3).
PMID: 34761247
Omics experiments are ubiquitous in biological studies, leading to a deluge of data. However, it is still challenging to connect changes in these data to changes in cell functions because...