Jian-Zhong Chen
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Explore the profile of Jian-Zhong Chen including associated specialties, affiliations and a list of published articles.
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Citations
896
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Recent Articles
1.
Ren J, Chen Q, Ye H, Cao C, Guo Y, Yang J, et al.
Arch Toxicol
. 2024 Sep;
98(12):4077-4092.
PMID: 39292235
Reproductive toxicity is one of the important issues in chemical safety. Traditional laboratory testing methods are costly and time-consuming with raised ethical issues. Only a few in silico models have...
2.
Khan M, Ren J, Cao C, Ye H, Wang H, Guo Y, et al.
Front Pharmacol
. 2024 Sep;
15:1441587.
PMID: 39234116
Background: Chemicals may lead to acute liver injuries, posing a serious threat to human health. Achieving the precise safety profile of a compound is challenging due to the complex and...
3.
Khan M, Khan D, Akbar M, Wang H, Haq I, Chen J
Biotechnol J
. 2024 Feb;
19(2):e2300437.
PMID: 38403464
Psoriasis is a common immune-mediated skin condition characterized by aberrant keratinocytes and cell proliferation. The purpose of this study was to explore the FDA-approved drugs by 3D-QSAR pharmacophore model and...
4.
Cao C, Wang H, Yang J, Chen Q, Guo Y, Chen J
Comput Biol Med
. 2024 Feb;
171:108037.
PMID: 38377716
The development of deep learning models for predicting toxicological endpoints has shown great promise, but one of the challenges in the field is the accuracy and interpretability of these models....
5.
Guo Y, Wang H, Yang J, Chen Q, Cao C, Chen J
J Org Chem
. 2023 Jul;
88(15):10448-10459.
PMID: 37458429
An efficient radical cascade cyclization of unactivated alkenes toward the synthesis of a series of ring-fused quinazolinones has been developed in moderate to excellent yields using commercially available ethers, alkanes,...
6.
Khan M, Uzair M, Nazli A, Chen J
Eur J Med Chem
. 2022 Aug;
241:114658.
PMID: 35964426
Estrogen governs the regulations of various pathological and physiological actions throughout the body in both males and females. Generally, 17β-estradiol an endogenous estrogen is responsible for different health problems in...
7.
Khan M, Nazli A, Pan Y, Chen J
Curr Med Chem
. 2022 Aug;
30(14):1576-1622.
PMID: 35927805
Background: PROTACs is an emerging technique that addresses the disease causing proteins by targeting protein degradation. PROTACs molecules are bifunctional small molecules that simultaneously bind to the protein of interest...
8.
Yang J, Chen Q, Wang H, Hu X, Guo Y, Chen J
Comput Biol Med
. 2022 May;
146:105573.
PMID: 35533460
Chromosome aberration (CA) is a serious genotoxicity of a compound, leading to carcinogenicity and developmental side effects. In the present manuscript, we developed a QSAR model for CA prediction using...
9.
Hu X, Xu H, Chen Q, Pan Y, Chen J
Org Biomol Chem
. 2021 Nov;
19(47):10376-10384.
PMID: 34812822
In the present studies, we describe a convenient and efficient protocol for the synthesis of the indolo[2,1-]isoquinoline core structure through the reaction of 2-aryl--acryloyl indoles and aryl or alkyl α-keto...
10.
Pan Y, Xu H, Hu X, Li G, Chen J
Org Biomol Chem
. 2021 May;
19(17):3911-3924.
PMID: 33949415
The regioselective direct C3-esterification of indoles with OXA is developed in an efficient reaction with carboxylic acids using the catalyst CuBr2 and oxidants Ag2CO3 and K2S2O8. The simple experimental procedure...