Jian-Zhong Chen
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Explore the profile of Jian-Zhong Chen including associated specialties, affiliations and a list of published articles.
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77
Citations
896
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Recent Articles
11.
Liu X, Zhao Y, Jia G, Yang F, Zhang C, Han B, et al.
Br J Clin Pharmacol
. 2021 Jan;
87(8):3292-3300.
PMID: 33506975
Aims: This open-label, phase I study evaluated the pharmacokinetics and safety of pegylated recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF) for the treatment of chemotherapy-induced neutropenia in children with acute leukaemia....
12.
Xu H, Pan Y, Li G, Hu X, Chen J
J Org Chem
. 2021 Jan;
86(2):1789-1801.
PMID: 33393296
The regioselective arylation of inert C3-H bonds in indoles reacting with arylboronates effective copper-mediated catalysis with the aid of a facile and removable 2-pyridinylisopropyl (PIP) group without ligand participation is...
13.
Liu Y, Pan Y, Li G, Xu H, Chen J
Org Biomol Chem
. 2019 Sep;
17(38):8749-8755.
PMID: 31549131
A direct coupling of 2H-indazoles' C3 position and acyl groups has been achieved to produce 3-acyl-2H-indazoles. The Ni(ii)-catalyzed acylation might proceed through a radical pathway for the reaction of 2H-indazoles...
14.
Li G, Pan Y, Liu Y, Xu H, Chen J
Org Lett
. 2019 Feb;
21(6):1740-1743.
PMID: 30802072
Here we reported a method for Cu-catalyzed ortho-acyloxylation of either the C(sp)-H or C(sp)-X (X = Cl, Br) bond of aromatic amides with carboxylic acid, especially olefine acids, to obtain...
15.
Qian H, Wang Z, Chen L, Pan Y, Xie X, Xie X, et al.
ChemMedChem
. 2018 Sep;
13(22):2455-2463.
PMID: 30246417
Herein we describe the design and synthesis of a new series of heteroarylpyrimidine/heteroaryltriazine derivatives on the basis of quinazoline-2,4(1H,3H)-diones as CB R-selective ligands using a bioisosterism strategy. An acetamide group...
16.
Pan Y, Liu Y, Chen J
Molecules
. 2018 Mar;
23(4).
PMID: 29584670
Fibroblast growth factor receptor 1 (FGFR1) has become a potential target for the treatment of cancer. Designing FGFR1-selective inhibitors remains fundamental to the development of anti-cancer drugs because of highly...
17.
Zhang Z, Chen F, Chen J
World J Pediatr
. 2018 Mar;
14(3):274-279.
PMID: 29508365
Background: This study aimed to investigate the effect of antibiotic stewardship programs (ASP) on reducing antimicrobial resistance rate, antibiotics consumption and multi-drug resistance bacterial infections in the pediatric patients. Methods:...
18.
Xia Y, Jiang X, Jiang S, He X, Luo J, Liu Z, et al.
Mol Med Rep
. 2017 Sep;
16(5):6882-6889.
PMID: 28901473
Prolyl hydroxylase 3 (PHD3) is widely accepted as a tumor suppressor; however, the expression of PHD3 in various cancer types remains controversial. The present study aimed to investigate the association...
19.
Hong B, Liu H, Wang Z, Zhu Y, Su L, Zhang M, et al.
Immunol Lett
. 2017 Sep;
190:265-271.
PMID: 28855128
Liver transplantation has emerged as a vital therapy for end-stage liver diseases. Acute -phase inflammation play an important role in liver graft injury.Recent studies have revealed that inflammasome are responsible...
20.
Shi Y, Duan Y, Ji Y, Wang Z, Wu Y, Gunosewoyo H, et al.
J Med Chem
. 2017 Jul;
60(16):7067-7083.
PMID: 28726401
Selective CB agonists represent an attractive therapeutic strategy for the treatment of a variety of diseases without psychiatric side effects mediated by the CB receptor. We carried out a rational...