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Jia-Yun Chen

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Articles 36
Citations 934
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Recent Articles
1.
Yu W, Barrett J, Tong J, Lin M, Marohn M, Devlin J, et al.
Immunity . 2024 Dec; 57(12):2827-2842.e5. PMID: 39662091
Hidradenitis suppurativa (HS) is a chronic, debilitating inflammatory skin disease characterized by keratinized epithelial tunnels that grow deeply into the dermis. Here, we examined the immune microenvironment within human HS...
2.
Ke S, Dang F, Wang L, Chen J, Naik M, Li W, et al.
Nat Commun . 2024 Apr; 15(1):3220. PMID: 38622115
Induced oncoproteins degradation provides an attractive anti-cancer modality. Activation of anaphase-promoting complex (APC/C) prevents cell-cycle entry by targeting crucial mitotic proteins for degradation. Phosphorylation of its co-activator CDH1 modulates the...
3.
Chen J, Wang Y, Xi H, Tao H, Zhao Q, Yu M, et al.
Qual Life Res . 2023 Jul; 32(12):3417-3426. PMID: 37481482
Purpose: Chronic pancreatitis (CP) is a chronic fibroinflammatory pancreatic disease that severely impacts patients' quality of life (QoL). The Pancreatitis Quality of Life Instrument (PANQOLI) is an 18-item measure specifically...
4.
He X, Chen J, Feng Y, Song P, Wong Y, Xie L, et al.
Acta Pharmacol Sin . 2023 Apr; 44(9):1801-1814. PMID: 37041228
Liver, as an immune and detoxification organ, represents an important line of defense against bacteria and infection and a vulnerable organ that is easily injured during sepsis. Artesunate (ART) is...
5.
Jiang C, Xu J, Xu C, Chen S, Chen J, Xia J, et al.
BMC Public Health . 2023 Mar; 23(1):574. PMID: 36978067
Background: Probiotics have been deemed multipotent and unprecedentedly applied in the health field recently. However, there are challenges in promoting credible and reliable resources while avoiding misinformation regarding probiotics for...
6.
Chen J, Hug C, Reyes J, Tian C, Gerosa L, Frohlich F, et al.
Cell Rep . 2023 Mar; 42(3):112252. PMID: 36920903
Oncogene-induced senescence is a phenomenon in which aberrant oncogene expression causes non-transformed cells to enter a non-proliferative state. Cells undergoing oncogenic induction display phenotypic heterogeneity, with some cells senescing and...
7.
Chen J, Wu J, Xu R, Hua Z, Gu L
Water Sci Technol . 2023 Mar; 87(5):1187-1201. PMID: 36919742
Inner coastal wetland ecosystems are generally eutrophic and are often exposed to both salinity stress and Escherichia coli pollution. However, the effects of these stressors on nutrient-cycling and microbial communities...
8.
Ke S, Dang F, Wang L, Chen J, Naik M, Thavamani A, et al.
Res Sq . 2023 Jan; PMID: 36711754
Cyclin-dependent kinases (CDKs) mediated phosphorylation inactivates the anaphase-promoting complex (APC/C), an E3 ubiquitin ligase that contains the co-activator CDH1, to promote G1/S transition. PIN1 is a phosphorylation-directed proline isomerase and...
9.
Jiang C, Fang X, Huang W, Guo J, Chen J, Wu H, et al.
Microbiol Spectr . 2022 Oct; 10(5):e0189922. PMID: 36197290
Maintaining the health of seafarers is a difficult task during long-term voyages. Little is known about the corresponding changes in the gut microbiome-host interaction. This study recruited 30 seafarers undertaking...
10.
Gao P, Liu Y, Xiao W, Xia F, Chen J, Gu L, et al.
Mil Med Res . 2022 Jun; 9(1):30. PMID: 35698214
Background: Malaria is a devastating infectious disease that disproportionally threatens hundreds of millions of people in developing countries. In the history of anti-malaria campaign, chloroquine (CQ) has played an indispensable...