Jessica P Alexander
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Explore the profile of Jessica P Alexander including associated specialties, affiliations and a list of published articles.
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10
Citations
663
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Recent Articles
1.
Clapper J, Henry C, Niphakis M, Knize A, Coppola A, Simon G, et al.
J Pharmacol Exp Ther
. 2018 Oct;
367(3):494-508.
PMID: 30305428
Monoacylglycerol lipase (MGLL) is the primary degradative enzyme for the endocannabinoid 2-arachidonoylglycerol (2-AG). The first MGLL inhibitors have recently entered clinical development for the treatment of neurologic disorders. To support...
2.
Cisar J, Weber O, Clapper J, Blankman J, Henry C, Simon G, et al.
J Med Chem
. 2018 Aug;
61(20):9062-9084.
PMID: 30067909
The serine hydrolase monoacylglycerol lipase (MGLL) converts the endogenous cannabinoid receptor agonist 2-arachidonoylglycerol (2-AG) and other monoacylglycerols into fatty acids and glycerol. Genetic or pharmacological inactivation of MGLL leads to...
3.
Chobanian H, Guo Y, Liu P, Chioda M, Fung S, Lanza T, et al.
ACS Med Chem Lett
. 2014 Jun;
5(6):717-21.
PMID: 24944750
We report herein the identification of MK-4409, a potent and selective fatty acid amide hydrolase (FAAH) inhibitor. Starting from a high throughput screening (HTS) hit, medicinal chemistry efforts focused on...
4.
Moy L, Jia Y, Caniga M, Lieber G, Gil M, Fernandez X, et al.
Am J Respir Cell Mol Biol
. 2013 Jul;
49(6):1085-92.
PMID: 23889698
Spleen tyrosine kinase (SYK) is a key activator of signaling pathways downstream of multiple surface receptors implicated in asthma. SYK function has been extensively studied in mast cells downstream of...
5.
Marrs W, Blankman J, Horne E, Thomazeau A, Lin Y, Coy J, et al.
Nat Neurosci
. 2010 Jul;
13(8):951-7.
PMID: 20657592
The endocannabinoid 2-arachidonoylglycerol (2-AG) regulates neurotransmission and neuroinflammation by activating CB1 cannabinoid receptors on neurons and CB2 cannabinoid receptors on microglia. Enzymes that hydrolyze 2-AG, such as monoacylglycerol lipase, regulate...
6.
Alexander J, Ryan T, Ballou D, Coward J
Biochemistry
. 2008 Jan;
47(4):1228-39.
PMID: 18171026
Gamma-glutamyl hydrolase, a cysteine peptidase, catalyzes the hydrolysis of poly-gamma-glutamate derivatives of folate cofactors and many antifolate drugs. We have used internally quenched fluorogenic derivatives of glutamyl-gamma-glutamate and (4,4-difluoro)glutamyl-gamma-glutamate to...
7.
Ahn K, Johnson D, Fitzgerald L, Liimatta M, Arendse A, Stevenson T, et al.
Biochemistry
. 2007 Oct;
46(45):13019-30.
PMID: 17949010
Fatty acid amide hydrolase (FAAH) is an integral membrane enzyme that degrades the fatty acid amide family of signaling lipids, including the endocannabinoid anandamide. Genetic or pharmacological inactivation of FAAH...
8.
Alexander J, Cravatt B
J Am Chem Soc
. 2006 Jul;
128(30):9699-704.
PMID: 16866524
How lipid transmitters move within and between cells to communicate signals remains an important and largely unanswered question. Integral membrane transporters, soluble lipid-binding proteins, and metabolic enzymes have all been...
9.
Alexander J, Cravatt B
Chem Biol
. 2005 Nov;
12(11):1179-87.
PMID: 16298297
Fatty acid amide hydrolase (FAAH) regulates a large class of signaling lipids, including the endocannabinoid anandamide. Carbamate inhibitors of FAAH display analgesic and anxiolytic properties in rodents. However, the mechanism...
10.
Hogestatt E, Jonsson B, Ermund A, Andersson D, Bjork H, Alexander J, et al.
J Biol Chem
. 2005 Jul;
280(36):31405-12.
PMID: 15987694
Acetaminophen (paracetamol) is a popular domestic analgesic and antipyretic agent with a weak anti-inflammatory action and a low incidence of adverse effects as compared with aspirin and other non-steroidal anti-inflammatory...