Jason R Clapper
Overview
Explore the profile of Jason R Clapper including associated specialties, affiliations and a list of published articles.
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16
Citations
717
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Recent Articles
1.
Clapper J, Henry C, Niphakis M, Knize A, Coppola A, Simon G, et al.
J Pharmacol Exp Ther
. 2018 Oct;
367(3):494-508.
PMID: 30305428
Monoacylglycerol lipase (MGLL) is the primary degradative enzyme for the endocannabinoid 2-arachidonoylglycerol (2-AG). The first MGLL inhibitors have recently entered clinical development for the treatment of neurologic disorders. To support...
2.
Cisar J, Weber O, Clapper J, Blankman J, Henry C, Simon G, et al.
J Med Chem
. 2018 Aug;
61(20):9062-9084.
PMID: 30067909
The serine hydrolase monoacylglycerol lipase (MGLL) converts the endogenous cannabinoid receptor agonist 2-arachidonoylglycerol (2-AG) and other monoacylglycerols into fatty acids and glycerol. Genetic or pharmacological inactivation of MGLL leads to...
3.
Clapper J, Hendricks M, Gu G, Wittmer C, Dolman C, Herich J, et al.
Am J Physiol Gastrointest Liver Physiol
. 2013 Jul;
305(7):G483-95.
PMID: 23886860
Shortcomings of previously reported preclinical models of nonalcoholic steatohepatitis (NASH) include inadequate methods used to induce disease and assess liver pathology. We have developed a dietary model of NASH displaying...
4.
Clapper J, Athanacio J, Wittmer C, Griffin P, DSouza L, Parkes D, et al.
Eur J Pharmacol
. 2012 Nov;
698(1-3):292-8.
PMID: 23178527
Antagonism of opioid systems (e.g., with naltrexone) has been explored as an anti-obesity strategy, and is particularly effective when co-administered with dual inhibitors of dopamine and norepinephrine reuptake (e.g., bupropion)....
5.
Jung K, Clapper J, Fu J, DAgostino G, Guijarro A, Thongkham D, et al.
Cell Metab
. 2012 Mar;
15(3):299-310.
PMID: 22405068
The endocannabinoid system plays a critical role in the control of energy homeostasis, but the identity and localization of the endocannabinoid signal involved remain unknown. In the present study, we...
6.
Vacondio F, Silva C, Lodola A, Carmi C, Rivara S, Duranti A, et al.
Eur J Med Chem
. 2011 Aug;
46(9):4466-73.
PMID: 21820769
Secondary alkylcarbamic acid biphenyl-3-yl esters are a class of Fatty Acid Amide Hydrolase (FAAH) inhibitors, which include the reference compounds URB597 and URB694. Given the intrinsic reactivity of the carbamate...
7.
Clapper J, Moreno-Sanz G, Russo R, Guijarro A, Vacondio F, Duranti A, et al.
Nat Neurosci
. 2010 Sep;
13(10):1265-70.
PMID: 20852626
Peripheral cannabinoid receptors exert a powerful inhibitory control over pain initiation, but the endocannabinoid signal that normally engages this intrinsic analgesic mechanism is unknown. To address this question, we developed...
8.
Eisenstein S, Clapper J, Holmes P, Piomelli D, Hohmann A
Pharmacol Res
. 2010 Jan;
61(5):419-29.
PMID: 20044005
Bilateral olfactory bulbectomy (OBX) in rodents produces behavioral and neurochemical changes associated clinically with depression and schizophrenia. Most notably, OBX induces hyperlocomotion in response to the stress of exposure to...
9.
Clapper J, Vacondio F, King A, Duranti A, Tontini A, Silva C, et al.
ChemMedChem
. 2009 Jul;
4(9):1505-13.
PMID: 19637155
The fatty acid ethanolamides are a class of signaling lipids that include agonists at cannabinoid and alpha type peroxisome proliferator-activated receptors (PPARalpha). In the brain, these compounds are primarily hydrolyzed...
10.
Vacondio F, Silva C, Lodola A, Fioni A, Rivara S, Duranti A, et al.
ChemMedChem
. 2009 Jun;
4(9):1495-504.
PMID: 19554599
Cyclohexylcarbamic acid aryl esters are a class of fatty acid amide hydrolase (FAAH) inhibitors, which includes the reference compound URB597. The reactivity of their carbamate fragment is involved in pharmacological...