Jessica N Spradlin
Overview
Explore the profile of Jessica N Spradlin including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
14
Citations
638
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Henning N, Manford A, Spradlin J, Brittain S, Zhang E, McKenna J, et al.
J Am Chem Soc
. 2023 Sep;
145(38):21142.
PMID: 37708357
No abstract available.
2.
Moon P, Zammit C, Shao Q, Dovala D, Boike L, Henning N, et al.
Chembiochem
. 2023 Apr;
24(11):e202300116.
PMID: 37069799
While vaccines and antivirals are now being deployed for the current SARS-CoV-2 pandemic, we require additional antiviral therapeutics to not only effectively combat SARS-CoV-2 and its variants, but also future...
3.
Page A, Scholz S, Keenan K, Spradlin J, Belcher B, Brittain S, et al.
Chem Sci
. 2022 Apr;
13(13):3851-3856.
PMID: 35432890
Photoaffinity labeling (PAL) is a powerful tool for the identification of non-covalent small molecule-protein interactions that are critical to drug discovery and medicinal chemistry, but this approach is limited to...
4.
Fischer C, Veprek N, Peitsinis Z, Ruhmann K, Yang C, Spradlin J, et al.
Synlett
. 2022 Mar;
33(5):458-463.
PMID: 35282568
The COVID-19 pandemic prompted many scientists to investigate remedies against SARS-CoV-2 and related viruses that are likely to appear in the future. As the main protease of the virus, M,...
5.
Henning N, Boike L, Spradlin J, Ward C, Liu G, Zhang E, et al.
Nat Chem Biol
. 2022 Feb;
18(4):412-421.
PMID: 35210618
Many diseases are driven by proteins that are aberrantly ubiquitinated and degraded. These diseases would be therapeutically benefited by targeted protein stabilization (TPS). Here we present deubiquitinase-targeting chimeras (DUBTACs), heterobifunctional...
6.
Henning N, Manford A, Spradlin J, Brittain S, Zhang E, McKenna J, et al.
J Am Chem Soc
. 2022 Jan;
144(2):701-708.
PMID: 34994556
Proteolysis-targeting chimeras (PROTACs), heterobifunctional compounds that consist of protein-targeting ligands linked to an E3 ligase recruiter, have arisen as a powerful therapeutic modality for targeted protein degradation (TPD). Despite the...
7.
Biering S, Van Dis E, Wehri E, Yamashiro L, Nguyenla X, Dugast-Darzacq C, et al.
ACS Infect Dis
. 2021 Jun;
7(8):2337-2351.
PMID: 34129317
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), has emerged as a major global health threat. The COVID-19 pandemic has resulted in over...
8.
Spradlin J, Zhang E, Nomura D
Acc Chem Res
. 2021 Mar;
54(7):1801-1813.
PMID: 33733731
One of the biggest bottlenecks in modern drug discovery efforts is in tackling the undruggable proteome. Currently, over 85% of the proteome is still considered undruggable because most proteins lack...
9.
Luo M, Spradlin J, Boike L, Tong B, Brittain S, McKenna J, et al.
Cell Chem Biol
. 2021 Jan;
28(4):559-566.e15.
PMID: 33513350
The translation of functionally active natural products into fully synthetic small-molecule mimetics has remained an important process in medicinal chemistry. We recently discovered that the terpene natural product nimbolide can...
10.
Tong B, Luo M, Xie Y, Spradlin J, Tallarico J, McKenna J, et al.
Sci Rep
. 2020 Sep;
10(1):15543.
PMID: 32968148
Targeted protein degradation (TPD) has emerged as a powerful tool in drug discovery for the perturbation of protein levels using heterobifunctional small molecules. E3 ligase recruiters remain central to this...