Jeffrey M McKenna
Overview
Explore the profile of Jeffrey M McKenna including associated specialties, affiliations and a list of published articles.
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Articles
31
Citations
1094
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Recent Articles
1.
Rosen H, Li K, Li E, Currier B, Brittain S, Garcia F, et al.
bioRxiv
. 2025 Mar;
PMID: 40060528
While MYC is a significant oncogenic transcription factor driver of cancer, directly targeting MYC has remained challenging due to its intrinsic disorder and poorly defined structure, deeming it "undruggable." Whether...
2.
Reilly J, Lozach M, Meishammer A, Reck M, Fairhurst R, McKenna J, et al.
J Chromatogr A
. 2025 Feb;
1744:465720.
PMID: 39892265
The advantages of a streamlined SFC chiral workflow for preparative chromatographic resolution of the enantiomers of investigational new compounds for pharmaceutical discovery on 10-20 mg scale with on-line chiroptical detection...
3.
Xie X, Moon P, Crossley S, Bischoff A, He D, Li G, et al.
Nature
. 2025 Jan;
637(8047):E24.
PMID: 39748037
No abstract available.
4.
Gowans F, Thach D, Zhu Z, Wang Y, Altamirano Poblano B, Dovala D, et al.
ACS Chem Biol
. 2024 May;
19(6):1260-1270.
PMID: 38739449
Ophiobolin A (OPA) is a sesterterpenoid fungal natural product with broad anticancer activity. While OPA possesses multiple electrophilic moieties that can covalently react with nucleophilic amino acids on proteins, the...
5.
Xie X, Moon P, Crossley S, Bischoff A, He D, Li G, et al.
Nature
. 2024 Mar;
627(8004):680-687.
PMID: 38448587
Methods for selective covalent modification of amino acids on proteins can enable a diverse array of applications, spanning probes and modulators of protein function to proteomics. Owing to their high...
6.
Henning N, Manford A, Spradlin J, Brittain S, Zhang E, McKenna J, et al.
J Am Chem Soc
. 2023 Sep;
145(38):21142.
PMID: 37708357
No abstract available.
7.
Toriki E, Papatzimas J, Nishikawa K, Dovala D, Frank A, Hesse M, et al.
ACS Cent Sci
. 2023 Aug;
9(8):1702.
PMID: 37637749
[This corrects the article DOI: 10.1021/acscentsci.2c01317.].
8.
Toriki E, Papatzimas J, Nishikawa K, Dovala D, Frank A, Hesse M, et al.
ACS Cent Sci
. 2023 May;
9(5):915-926.
PMID: 37252349
Targeted protein degradation with molecular glue degraders has arisen as a powerful therapeutic modality for eliminating classically undruggable disease-causing proteins through proteasome-mediated degradation. However, we currently lack rational chemical design...
9.
Moon P, Zammit C, Shao Q, Dovala D, Boike L, Henning N, et al.
Chembiochem
. 2023 Apr;
24(11):e202300116.
PMID: 37069799
While vaccines and antivirals are now being deployed for the current SARS-CoV-2 pandemic, we require additional antiviral therapeutics to not only effectively combat SARS-CoV-2 and its variants, but also future...
10.
Gowans F, Thach D, Wang Y, Altamirano Poblano B, Dovala D, Tallarico J, et al.
bioRxiv
. 2023 Mar;
PMID: 36945520
Ophiobolin A (OPA) is a sesterterpenoid fungal natural product with broad anti-cancer activity. While OPA possesses multiple electrophilic moieties that can covalently react with nucleophilic amino acids on proteins, the...