Jessica Marinello
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Explore the profile of Jessica Marinello including associated specialties, affiliations and a list of published articles.
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28
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1010
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Recent Articles
1.
Miglietta G, Russo M, Capranico G, Marinello J
Br J Cancer
. 2024 Aug;
131(10):1567-1575.
PMID: 39215193
Lung cancer has a significant incidence among the population and, unfortunately, has an unfavourable prognosis in most cases. The World Health Organization (WHO) classifies lung tumours into two subtypes based...
2.
Duardo R, Marinello J, Russo M, Morelli S, Pepe S, Guerra F, et al.
Sci Adv
. 2024 May;
10(21):eadm8196.
PMID: 38787953
DNA topoisomerase I can contribute to cancer genome instability. During catalytic activity, topoisomerase I forms a transient intermediate, topoisomerase I-DNA cleavage complex (Top1cc) to allow strand rotation and duplex relaxation,...
3.
Geraud M, Cristini A, Salimbeni S, Bery N, Jouffret V, Russo M, et al.
Cell Rep
. 2024 May;
43(5):114214.
PMID: 38761375
TDP1 removes transcription-blocking topoisomerase I cleavage complexes (TOP1ccs), and its inactivating H493R mutation causes the neurodegenerative syndrome SCAN1. However, the molecular mechanism underlying the SCAN1 phenotype is unclear. Here, we...
4.
Miglietta G, Marinello J, Capranico G
Methods Enzymol
. 2024 Mar;
695:103-118.
PMID: 38521582
A large variety of non-B secondary structures can be formed between DNA and RNA. In this chapter, we focus on G-quadruplexes (G4) and R-loops, which can have a close structural...
5.
Miglietta G, Marinello J, Russo M, Capranico G
Mol Cancer
. 2022 Sep;
21(1):180.
PMID: 36114513
G-quadruplex (G4) binders have been investigated to discover new anticancer drugs worldwide in past decades. As these ligands are generally not highly cytotoxic, the discovery rational was mainly based on...
6.
Marzano S, Miglietta G, Morigi R, Marinello J, Arleo A, Procacci M, et al.
J Med Chem
. 2022 Sep;
65(18):12055-12067.
PMID: 36074772
G-quadruplex (G4) ligands are investigated to discover new anticancer drugs with increased cell-killing potency. These ligands can induce genome instability and activate innate immune genes at non-cytotoxic doses, opening the...
7.
Marinello J, Arleo A, Russo M, Delcuratolo M, Ciccarelli F, Pommier Y, et al.
Br J Cancer
. 2022 Jul;
127(7):1214-1225.
PMID: 35794238
Background: Current immunotherapy strategies have contrasting clinical results in human lung cancer patients as small-cell lung cancers (SCLC) often show features of immunological cold tumours. Topoisomerase 1 (TOP1) poisons are...
8.
Marinello J, Capranico G
Methods Mol Biol
. 2022 Jun;
2528:203-213.
PMID: 35704193
Topoisomerase 1-DNA cleavage complexes (Top1ccs) form at DNA sites of Top1 activity and are increased by a highly specific anticancer drug (camptothecin, CPT) in living cells. Various methods are available...
9.
Castro A, Marinello J, Chougui K, Morand M, Bilodeau C, Tsimicalis A
J Clin Nurs
. 2020 May;
29(15-16):2999-3011.
PMID: 32350946
Aims And Objectives: To explore the day-to-day experiences of family caregivers who are caring for children with Osteogenesis Imperfecta (OI). Background: Osteogenesis Imperfecta is a rare genetic condition known to...
10.
Cristini A, Ricci G, Britton S, Salimbeni S, Huang S, Marinello J, et al.
Cell Rep
. 2019 Sep;
28(12):3167-3181.e6.
PMID: 31533039
Although accumulation of DNA damage and genomic instability in resting cells can cause neurodegenerative disorders, our understanding of how transcription produces DNA double-strand breaks (DSBs) is limited. Transcription-blocking topoisomerase I...