Giovanni Capranico
Overview
Explore the profile of Giovanni Capranico including associated specialties, affiliations and a list of published articles.
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61
Citations
1316
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Recent Articles
1.
Miglietta G, Russo M, Capranico G, Marinello J
Br J Cancer
. 2024 Aug;
131(10):1567-1575.
PMID: 39215193
Lung cancer has a significant incidence among the population and, unfortunately, has an unfavourable prognosis in most cases. The World Health Organization (WHO) classifies lung tumours into two subtypes based...
2.
Duardo R, Marinello J, Russo M, Morelli S, Pepe S, Guerra F, et al.
Sci Adv
. 2024 May;
10(21):eadm8196.
PMID: 38787953
DNA topoisomerase I can contribute to cancer genome instability. During catalytic activity, topoisomerase I forms a transient intermediate, topoisomerase I-DNA cleavage complex (Top1cc) to allow strand rotation and duplex relaxation,...
3.
Geraud M, Cristini A, Salimbeni S, Bery N, Jouffret V, Russo M, et al.
Cell Rep
. 2024 May;
43(5):114214.
PMID: 38761375
TDP1 removes transcription-blocking topoisomerase I cleavage complexes (TOP1ccs), and its inactivating H493R mutation causes the neurodegenerative syndrome SCAN1. However, the molecular mechanism underlying the SCAN1 phenotype is unclear. Here, we...
4.
Miglietta G, Marinello J, Capranico G
Methods Enzymol
. 2024 Mar;
695:103-118.
PMID: 38521582
A large variety of non-B secondary structures can be formed between DNA and RNA. In this chapter, we focus on G-quadruplexes (G4) and R-loops, which can have a close structural...
5.
Mergny J, Trantirek L, Capranico G
Biochimie
. 2023 Sep;
214(Pt A):1-4.
PMID: 37748749
No abstract available.
6.
Duardo R, Guerra F, Pepe S, Capranico G
Biochimie
. 2023 Jul;
214(Pt A):176-192.
PMID: 37429410
Non-canonical secondary structures (NCSs) are alternative nucleic acid structures that differ from the canonical B-DNA conformation. NCSs often occur in repetitive DNA sequences and can adopt different conformations depending on...
7.
De Rosa P, Severi F, Zadran S, Russo M, Aloisi S, Rigamonti A, et al.
Int J Mol Sci
. 2023 Mar;
24(6).
PMID: 36982482
Neuroblastoma (NB) is one of the primary causes of death for pediatric malignancies. Given the high heterogeneity in NB's mutation landscape, optimizing individualized therapies is still challenging. In the context...
8.
Russo M, Morelli S, Capranico G
Mob DNA
. 2023 Mar;
14(1):2.
PMID: 36918931
Small-cell lung cancer (SCLC) is an aggressive cancer characterized by immunosuppressive features leading to poor responses to current immunotherapies. Activation of transposable elements (TE) can trigger an innate immune response,...
9.
Miglietta G, Marinello J, Russo M, Capranico G
Mol Cancer
. 2022 Sep;
21(1):180.
PMID: 36114513
G-quadruplex (G4) binders have been investigated to discover new anticancer drugs worldwide in past decades. As these ligands are generally not highly cytotoxic, the discovery rational was mainly based on...
10.
Marzano S, Miglietta G, Morigi R, Marinello J, Arleo A, Procacci M, et al.
J Med Chem
. 2022 Sep;
65(18):12055-12067.
PMID: 36074772
G-quadruplex (G4) ligands are investigated to discover new anticancer drugs with increased cell-killing potency. These ligands can induce genome instability and activate innate immune genes at non-cytotoxic doses, opening the...