Jesper Tegner
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Explore the profile of Jesper Tegner including associated specialties, affiliations and a list of published articles.
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Articles
137
Citations
4995
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Recent Articles
1.
McManus R, Komes M, Griep A, Santarelli F, Schwartz S, Ramon Perea J, et al.
Immunity
. 2025 Feb;
58(2):326-343.e11.
PMID: 39904338
Activation of the NLRP3 inflammasome has been implicated in the pathogenesis of Alzheimer's disease (AD) via the release of IL-1β and ASC specks. However, whether NLRP3 is involved in pathways...
2.
Zhong H, Han W, Gomez-Cabrero D, Tegner J, Gao X, Cui G, et al.
Nucleic Acids Res
. 2025 Jan;
53(1.
PMID: 39778870
Cross-species single-cell RNA-seq data hold immense potential for unraveling cell type evolution and transferring knowledge between well-explored and less-studied species. However, challenges arise from interspecific genetic variation, batch effects stemming...
3.
Ortega-Legarreta A, Palomino-Echeverria S, Huergo E, Lagani V, Kiani N, Rautou P, et al.
PLoS Comput Biol
. 2024 Dec;
20(12):e1012656.
PMID: 39671459
In the era of precision medicine, it is necessary to understand heterogeneity among patients with complex diseases to improve personalized prevention and management strategies. Here, we introduce ClustAll, a Bioconductor...
4.
Zhang H, Maillo A, Khan S, Martinez-de-Morentin X, Lehmann R, Gomez-Cabrero D, et al.
Comput Struct Biotechnol J
. 2024 Nov;
23:3989-3998.
PMID: 39582890
In today's scientific landscape, research software has evolved from being a supportive tool to becoming a fundamental driver of discovery, particularly in life sciences. Beyond its roots in software engineering,...
5.
de Weerd H, Guala D, Gustafsson M, Synnergren J, Tegner J, Lubovac-Pilav Z, et al.
Patterns (N Y)
. 2024 Nov;
5(11):101093.
PMID: 39568475
Computational analyses of transcriptomic data have dramatically improved our understanding of complex diseases. However, such approaches are limited by small sample sets of disease-affected material. We asked if a variational...
6.
Balubaid A, Alsolami S, Kiani N, Gomez-Cabrero D, Li M, Tegner J
iScience
. 2024 Nov;
27(11):111122.
PMID: 39524369
Pluripotent-stem-cell-derived blastocyst-like structures (blastoids) offer insights into early human embryogenesis (5-10 days post-fertilization). The similarity between blastoids and human blastocysts remains uncertain. To investigate, we evaluated single-cell RNA sequencing (scRNAseq)...
7.
Palomino-Echeverria S, Huergo E, Ortega-Legarreta A, Uson Raposo E, Aguilar F, de la Pena-Ramirez C, et al.
J Transl Med
. 2024 Jun;
22(1):599.
PMID: 38937846
Background: Patient heterogeneity poses significant challenges for managing individuals and designing clinical trials, especially in complex diseases. Existing classifications rely on outcome-predicting scores, potentially overlooking crucial elements contributing to heterogeneity...
8.
Alowaysi M, Lehmann R, Al-Shehri M, Baadhaim M, Alzahrani H, Aboalola D, et al.
Stem Cell Res Ther
. 2023 Dec;
14(1):374.
PMID: 38111036
Background: Human iPSCs' derivation and use in clinical studies are transforming medicine. Yet, there is a high cost and long waiting time associated with autologous iPS-based cellular therapy, and the...
9.
Alowaysi M, Al-Shehri M, Badkok A, Attas H, Aboalola D, Baadhaim M, et al.
Hum Cell
. 2023 Dec;
37(2):502-510.
PMID: 38110787
The most prevalent form of epileptic encephalopathy is Dravet syndrome (DRVT), which is triggered by the pathogenic variant SCN1A in 80% of cases. iPSCs with different SCN1A mutations have been...
10.
Alowaysi M, Al-Shehri M, Baadhaim M, Alzahrani H, Aboalola D, Daghestani M, et al.
Stem Cell Res
. 2023 Jul;
71:103158.
PMID: 37406498
Myoglobin (MB) is a cytoplasmic hemoprotein that is predominantly expressed in the heart and oxidative myofibers of skeletal muscle. It has been demonstrated that MB binds to oxygen and promotes...