Aengus Stewart
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Explore the profile of Aengus Stewart including associated specialties, affiliations and a list of published articles.
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35
Citations
9442
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Recent Articles
1.
Cugusi S, Bajpe P, Mitter R, Patel H, Stewart A, Svejstrup J
Mol Cell Biol
. 2022 Sep;
42(10):e0017322.
PMID: 36121223
During the heat shock response (HSR), heat shock factor (HSF1 in mammals) binds to target gene promoters, resulting in increased expression of heat shock proteins that help maintain protein homeostasis...
2.
Cugusi S, Mitter R, Kelly G, Walker J, Han Z, Pisano P, et al.
Mol Cell
. 2022 Feb;
82(8):1573-1588.e10.
PMID: 35114099
The heat shock (HS) response involves rapid induction of HS genes, whereas transcriptional repression is established more slowly at most other genes. Previous data suggested that such repression results from...
3.
Kanagaraj R, Mitter R, Kantidakis T, Edwards M, Benitez A, Chakravarty P, et al.
Proc Natl Acad Sci U S A
. 2022 Jan;
119(4).
PMID: 35042798
Mutations in the gene, which encodes Senataxin, are associated with the progressive neurodegenerative diseases ataxia with oculomotor apraxia 2 (AOA2) and amyotrophic lateral sclerosis 4 (ALS4). To identify the causal...
4.
Wan L, Juszkiewicz S, Blears D, Bajpe P, Han Z, Faull P, et al.
Mol Cell
. 2021 Jun;
81(13):2808-2822.e10.
PMID: 34111399
The cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway senses cytosolic DNA and induces interferon-stimulated genes (ISGs) to activate the innate immune system. Here, we report the unexpected discovery that...
5.
Daniels R, Tse H, Ermetal B, Xiang Z, Jackson D, Guntoro J, et al.
J Virol
. 2020 Aug;
94(21).
PMID: 32817211
In 2014, the Centre for Health Protection in Hong Kong introduced screening for influenza C virus (ICV) as part of its routine surveillance for infectious agents in specimens collected from...
6.
Tufegdzic Vidakovic A, Mitter R, Kelly G, Neumann M, Harreman M, Rodriguez-Martinez M, et al.
Cell
. 2020 Mar;
180(6):1245-1261.e21.
PMID: 32142654
In response to transcription-blocking DNA damage, cells orchestrate a multi-pronged reaction, involving transcription-coupled DNA repair, degradation of RNA polymerase II (RNAPII), and genome-wide transcription shutdown. Here, we provide insight into...
7.
Zatreanu D, Han Z, Mitter R, Tumini E, Williams H, Gregersen L, et al.
Mol Cell
. 2019 Sep;
76(1):57-69.e9.
PMID: 31519522
Although correlations between RNA polymerase II (RNAPII) transcription stress, R-loops, and genome instability have been established, the mechanisms underlying these connections remain poorly understood. Here, we used a mutant version...
8.
Young J, Dominicus C, Wagener J, Butterworth S, Ye X, Kelly G, et al.
Nat Commun
. 2019 Sep;
10(1):3963.
PMID: 31481656
Genome-wide CRISPR screening is a powerful tool to identify genes required under selective conditions. However, the inherent scale of genome-wide libraries can limit their application in experimental settings where cell...
9.
Gregersen L, Mitter R, Ugalde A, Nojima T, Proudfoot N, Agami R, et al.
Cell
. 2019 May;
177(7):1797-1813.e18.
PMID: 31104839
Accurate regulation of mRNA termination is required for correct gene expression. Here, we describe a role for SCAF4 and SCAF8 as anti-terminators, suppressing the use of early, alternative polyadenylation (polyA)...
10.
Turajlic S, Xu H, Litchfield K, Rowan A, Chambers T, Lopez J, et al.
Cell
. 2018 Apr;
173(3):581-594.e12.
PMID: 29656895
Clear-cell renal cell carcinoma (ccRCC) exhibits a broad range of metastatic phenotypes that have not been systematically studied to date. Here, we analyzed 575 primary and 335 metastatic biopsies across...