Jerry L Workman
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Explore the profile of Jerry L Workman including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Suganuma T, Workman J
Redox Biol
. 2022 Feb;
51:102270.
PMID: 35189552
Overproduction of reactive oxygen species (ROS) drives inflammation and mutagenesis. However, the role of the DNA damage response in immune responses remains largely unknown. Here we found that stabilization of...
12.
Amigo R, Farkas C, Gidi C, Hepp M, Cartes N, Tarifeno E, et al.
Biochim Biophys Acta Gene Regul Mech
. 2021 Dec;
1865(1):194781.
PMID: 34963628
Diverse factors play roles in chromatin dynamics, including linker proteins. Among them are high mobility group (HMG) box family proteins and linker histones. In the yeast Saccharomyces cerevisiae, Hmo1 has...
13.
Soffers J, Alcantara S, Li X, Shao W, Seidel C, Li H, et al.
PLoS Genet
. 2021 Nov;
17(11):e1009668.
PMID: 34807910
The Spt/Ada-Gcn5 Acetyltransferase (SAGA) coactivator complex has multiple modules with different enzymatic and non-enzymatic functions. How each module contributes to gene expression is not well understood. During Drosophila oogenesis, the...
14.
Bhattacharya S, Wang S, Reddy D, Shen S, Zhang Y, Zhang N, et al.
Nat Commun
. 2021 Nov;
12(1):6452.
PMID: 34750379
The RNA recognition motif (RRM) binds to nucleic acids as well as proteins. More than one such domain is found in the pre-mRNA processing hnRNP proteins. While the mode of...
15.
Suganuma T, Swanson S, Gogol M, Garrett T, Florens L, Workman J
J Mol Cell Biol
. 2021 Oct;
13(11):838-840.
PMID: 34698840
No abstract available.
16.
Church M, Workman J, Suganuma T
Int J Mol Sci
. 2021 Oct;
22(19).
PMID: 34638614
Inflammation is the body's means of defense against harmful stimuli, with the ultimate aim being to restore homeostasis. Controlled acute inflammation transiently activates an immune response and can be beneficial...
17.
Suganuma T, Workman J
Front Endocrinol (Lausanne)
. 2021 Sep;
12:731648.
PMID: 34526971
The mechanisms of epigenetic gene regulation-histone modifications, chromatin remodeling, DNA methylation, and noncoding RNA-use metabolites as enzymatic cofactors and substrates in reactions that allow chromatin formation, nucleotide biogenesis, transcription, RNA...
18.
Bhattacharya S, Lange J, Levy M, Florens L, Washburn M, Workman J
J Biol Chem
. 2021 Aug;
297(3):101075.
PMID: 34391778
SETD2 is an important methyltransferase that methylates crucial substrates such as histone H3, tubulin, and STAT1 and also physically interacts with transcription and splicing regulators such as Pol II and...
19.
Chen W, Yu X, Wu Y, Tang J, Yu Q, Lv X, et al.
Nat Metab
. 2021 Jun;
3(7):983-1000.
PMID: 34183849
Acetyl-CoA is a central node in carbon metabolism and plays critical roles in regulatory and biosynthetic processes. The acetyl-CoA synthetase Acs2, which catalyses acetyl-CoA production from acetate, is an integral...
20.
Bhattacharya S, Levy M, Zhang N, Li H, Florens L, Washburn M, et al.
Nat Commun
. 2021 Mar;
12(1):1443.
PMID: 33664260
Heterogeneous ribonucleoproteins (hnRNPs) are RNA binding molecules that are involved in key processes such as RNA splicing and transcription. One such hnRNP protein, hnRNP L, regulates alternative splicing (AS) by...