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Jerome Rihon

Explore the profile of Jerome Rihon including associated specialties, affiliations and a list of published articles. Areas
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Articles 5
Citations 9
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Recent Articles
1.
Reynders S, Rihon J, Lescrinier E
J Chem Theory Comput . 2025 Jan; 21(5):2798-2814. PMID: 39869220
Synthetic nucleic acids, also defined as xenobiotic nucleic acids (XNAs), opened an avenue to address the limitations of nucleic acid therapeutics and the development of alternative carriers for genetic information...
2.
Rihon J, Mattelaer C, Montalvao R, Froeyen M, Pinheiro V, Lescrinier E
Nucleic Acids Res . 2024 Feb; 52(6):2836-2847. PMID: 38412249
The field of synthetic nucleic acids with novel backbone structures [xenobiotic nucleic acids (XNAs)] has flourished due to the increased importance of XNA antisense oligonucleotides and aptamers in medicine, as...
3.
Schofield P, Taylor A, Rihon J, Pena Martinez C, Zinn S, Mattelaer C, et al.
Nucleic Acids Res . 2023 Jul; 51(15):7736-7748. PMID: 37439359
Nucleic acids not only form the basis of heredity, but are increasingly a source of novel nano-structures, -devices and drugs. This has spurred the development of chemically modified alternatives (xeno...
4.
Xu Y, Groaz E, Rihon J, Herdewijn P, Lescrinier E
Eur J Med Chem . 2023 Apr; 255:115379. PMID: 37120998
Molecular dynamics (MD) simulations provided insights into the favorable interactions between xylose nucleosides bearing a phosphonate moiety at their 3'-position and specific residues at the active site of the archetypal...
5.
Depuydt A, Rihon J, Cheneval O, Vanmeert M, Schroeder C, Craik D, et al.
ACS Pharmacol Transl Sci . 2021 Aug; 4(4):1379-1389. PMID: 34423272
T-type calcium (Ca3) channels play a crucial role in the generation and propagation of action potentials in excitable cells and are considered potential drug targets for the treatment of neurological...
6.
Mattelaer C, Mattelaer H, Rihon J, Froeyen M, Lescrinier E
J Chem Theory Comput . 2021 May; 17(6):3814-3823. PMID: 34000809
Puckering of the sugar unit in nucleosides and nucleotides is an important structural aspect that directly influences the helical structure of nucleic acids. The preference for specific puckering modes in...