Jerome M Siegel
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Explore the profile of Jerome M Siegel including associated specialties, affiliations and a list of published articles.
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109
Citations
3724
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Recent Articles
1.
Malungo I, Ngwenya A, Bertelsen M, Spocter M, Thannickal T, Siegel J, et al.
J Comp Neurol
. 2025 Feb;
533(2):e70032.
PMID: 40008540
The phylogenetic contextualization of human neuroanatomy is crucial for understanding the positive, neutral, and/or negative effects of therapeutic interventions derived from animal models. Here we determined the parcellation of, and...
2.
McGregor R, Wu M, Thannickal T, Li S, Siegel J
Nat Ment Health
. 2025 Feb;
2(9):1018-1031.
PMID: 39989723
Heroin use disorder in humans and chronic opioid administration to mice result in an increase in the number and a decrease in the size of detected hypocretin (Hcrt, or orexin)...
3.
Thorpy M, Siegel J, Dauvilliers Y
Sleep Med Rev
. 2024 Aug;
77:101976.
PMID: 39186901
Narcolepsy is mainly associated with excessive daytime sleepiness, but the characteristic feature is abnormal rapid eye movement (REM) sleep phenomena. REM sleep disturbances can manifest as cataplexy (in narcolepsy type...
4.
Lyamin O, Siegel J
Curr Biol
. 2024 Mar;
34(5):R213-R216.
PMID: 38471454
A new study presents evidence of sex-related sleep reduction in males of two marsupial mice species but not in females. The growing experimental data suggest that seasonal sleep reduction, linked...
5.
McGregor R, Wu M, Thannickal T, Siegel J
bioRxiv
. 2023 Oct;
PMID: 37790444
We previously found that heroin addiction in humans is accompanied by an increase in the number of detected Hcrt neurons and a decrease in their soma size. We now show...
6.
Lyamin O, Borshchenko V, Siegel J
J Comp Physiol B
. 2023 Aug;
194(3):315-333.
PMID: 37596419
While the majority of studies have concluded that sleep deprivation causes detrimental effects on various cognitive processes, some studies reported conflicting results. We examined the effects of a 108-h total...
7.
Wu M, Thannickal T, Li S, McGregor R, Lai Y, Siegel J
Sleep
. 2023 May;
46(9).
PMID: 37155728
Long-term use of sodium oxybate (SXB), (also called gamma-hydroxybutyrate [GHB]) attenuates the cataplexy and sleepiness of human narcolepsy. We had previously found that chronic opiate usage in humans and long-term...
8.
McGregor R, Matzeu A, Thannickal T, Wu F, Cornford M, Martin-Fardon R, et al.
Neuroscience
. 2023 Apr;
522:1-10.
PMID: 37121379
Human heroin addicts and mice administered morphine for a 2 week period show a greatly increased number of hypothalamic hypocretin (Hcrt or orexin) producing neurons with a concomitant reduction in...
9.
Siegel J
Lancet Neurol
. 2022 Sep;
21(10):937-946.
PMID: 36115365
Prospective epidemiological studies in industrial societies indicate that 7 h of sleep per night in people aged 18 years or older is optimum, with higher and lower amounts of sleep...
10.
Salminen A, Clemens S, Garcia-Borreguero D, Ghorayeb I, Li Y, Manconi M, et al.
Dis Model Mech
. 2022 Aug;
15(8).
PMID: 35946581
Our understanding of the causes and natural course of restless legs syndrome (RLS) is incomplete. The lack of objective diagnostic biomarkers remains a challenge for clinical research and for the...