Ronald McGregor
Overview
Explore the profile of Ronald McGregor including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
324
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Recent Articles
1.
Richeri A, McGregor R, Scorza C
Neuroscience
. 2025 Mar;
PMID: 40073930
The number of people suffering from Substance Use Disorder (SUD) worldwide has increased 45 % compared to the last decade according to the latest United Nations World Drug Report. This...
2.
McGregor R, Wu M, Thannickal T, Li S, Siegel J
Nat Ment Health
. 2025 Feb;
2(9):1018-1031.
PMID: 39989723
Heroin use disorder in humans and chronic opioid administration to mice result in an increase in the number and a decrease in the size of detected hypocretin (Hcrt, or orexin)...
3.
McGregor R, Wu M, Thannickal T, Siegel J
bioRxiv
. 2023 Oct;
PMID: 37790444
We previously found that heroin addiction in humans is accompanied by an increase in the number of detected Hcrt neurons and a decrease in their soma size. We now show...
4.
Wu M, Thannickal T, Li S, McGregor R, Lai Y, Siegel J
Sleep
. 2023 May;
46(9).
PMID: 37155728
Long-term use of sodium oxybate (SXB), (also called gamma-hydroxybutyrate [GHB]) attenuates the cataplexy and sleepiness of human narcolepsy. We had previously found that chronic opiate usage in humans and long-term...
5.
McGregor R, Matzeu A, Thannickal T, Wu F, Cornford M, Martin-Fardon R, et al.
Neuroscience
. 2023 Apr;
522:1-10.
PMID: 37121379
Human heroin addicts and mice administered morphine for a 2 week period show a greatly increased number of hypothalamic hypocretin (Hcrt or orexin) producing neurons with a concomitant reduction in...
6.
McGregor R, Wu M, Holmes B, Lam H, Maidment N, Gera J, et al.
J Neurosci
. 2021 Dec;
42(2):255-263.
PMID: 34853083
We previously found that human heroin addicts and mice chronically exposed to morphine exhibit a significant increase in the number of detected hypocretin/orexin (Hcrt)-producing neurons. However, it remains unknown how...
7.
McGregor R, Thannickal T, Siegel J
Handb Clin Neurol
. 2021 Jul;
180:359-374.
PMID: 34225941
The hypocretins/orexins were discovered in 1998. Within 2 years, this led to the discovery of the cause of human narcolepsy, a 90% loss of hypothalamic neurons containing these peptides. Further...
8.
Lopez Hill X, Richeri A, McGregor R, Acuna A, Scorza C
Brain Res
. 2019 May;
1718:176-185.
PMID: 31071305
Non-competitive N-methyl-d-aspartate receptor (NMDA-R) antagonists have been suggested to evoke psychotomimetic-like behaviors by selectively targeting GABAergic elements in cortical and thalamic circuits. In previous studies, we had reported the involvement...
9.
Thannickal T, John J, Shan L, Swaab D, Wu M, Ramanathan L, et al.
Sci Transl Med
. 2018 Jun;
10(447).
PMID: 29950444
The changes in brain function that perpetuate opiate addiction are unclear. In our studies of human narcolepsy, a disease caused by loss of immunohistochemically detected hypocretin (orexin) neurons, we encountered...
10.
McGregor R, Shan L, Wu M, Siegel J
PLoS One
. 2017 Jun;
12(6):e0178573.
PMID: 28570646
The loss of specific neuronal phenotypes, as determined by immunohistochemistry, has become a powerful tool for identifying the nature and cause of neurological diseases. Here we show that the number...