Jerome M Siegel
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Explore the profile of Jerome M Siegel including associated specialties, affiliations and a list of published articles.
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109
Citations
3724
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Recent Articles
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Lai Y, Hsieh K, Chew K, Nguyen D, Siegel J
Sleep
. 2022 May;
45(7).
PMID: 35537196
Study Objectives: Brain iron deficiency has been reported to be associated with the restless legs syndrome (RLS). However, 30%-50% of RLS patients do not respond to iron therapy, indicating that...
13.
Coleman P, De Lecea L, Gotter A, Hagan J, Hoyer D, Kilduff T, et al.
IUPHAR BPS Guide Pharm CITE
. 2021 Dec;
2021(3).
PMID: 34927075
Orexin receptors 42 are activated by the endogenous polypeptides orexin-A and orexin-B (also known as hypocretin-1 and -2; 33 and 28 aa) derived from a common precursor, preproorexin or orexin...
14.
Lyamin O, Siegel J
Handb Behav Neurosci
. 2021 Dec;
30:375-393.
PMID: 34899110
No abstract available.
15.
McGregor R, Wu M, Holmes B, Lam H, Maidment N, Gera J, et al.
J Neurosci
. 2021 Dec;
42(2):255-263.
PMID: 34853083
We previously found that human heroin addicts and mice chronically exposed to morphine exhibit a significant increase in the number of detected hypocretin/orexin (Hcrt)-producing neurons. However, it remains unknown how...
16.
Williams V, Bhagwandin A, Swiegers J, Bertelsen M, Hard T, Thannickal T, et al.
Anat Rec (Hoboken)
. 2021 Sep;
305(6):1459-1475.
PMID: 34535040
Employing orexin-A immunohistochemical staining we describe the nuclear parcellation of orexinergic neurons in the hypothalami of a lar gibbon and a chimpanzee. The clustering of orexinergic neurons within the hypothalamus...
17.
Siegel J
Curr Sleep Med Rep
. 2021 Sep;
7(1):15-18.
PMID: 34485023
Purpose Of Review: I review the current status of the hypothesis that sleep is critically involved in memory consolidation and conclude that there are major methodological problems with the studies...
18.
Lyamin O, Siegel J, Nazarenko E, Rozhnov V
Sleep
. 2021 Aug;
45(7).
PMID: 34370021
The mouse-deer or chevrotains are the smallest of the ungulates and ruminants. They are characterized by a number of traits which are considered plesiomorphic for the Artiodactyla order. The objective...
19.
McGregor R, Thannickal T, Siegel J
Handb Clin Neurol
. 2021 Jul;
180:359-374.
PMID: 34225941
The hypocretins/orexins were discovered in 1998. Within 2 years, this led to the discovery of the cause of human narcolepsy, a 90% loss of hypothalamic neurons containing these peptides. Further...
20.
Salminen A, Silvani A, Allen R, Clemens S, Garcia-Borreguero D, Ghorayeb I, et al.
Mov Disord
. 2020 Dec;
36(3):558-569.
PMID: 33382140
Restless legs syndrome (RLS) is a chronic sensorimotor disorder diagnosed by clinical symptoms. It is challenging to translate the diagnostic self-reported features of RLS to animals. To help researchers design...