Jeroen Witteveldt
Overview
Explore the profile of Jeroen Witteveldt including associated specialties, affiliations and a list of published articles.
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Articles
22
Citations
756
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Recent Articles
1.
Mueller F, Witteveldt J, Macias S
Viruses
. 2024 Feb;
16(2).
PMID: 38399949
The type-I interferon (IFN) response constitutes the major innate immune pathway against viruses in mammals. Despite its critical importance for antiviral defence, this pathway is inactive during early embryonic development....
2.
Gazquez-Gutierrez A, Witteveldt J, Heras S, Macias S
RNA
. 2021 Apr;
PMID: 33888553
Around half of the genome in mammals is composed of transposable elements (TEs) such as DNA transposons and retrotransposons. Several mechanisms have evolved to prevent their activity and the detrimental...
3.
Witteveldt J, Macias S
Bio Protoc
. 2021 Mar;
9(21):e3417.
PMID: 33654916
Controlled differentiation of embryonic stem cells is an essential tool in stem cell research. In this protocol, we describe a simple differentiation protocol involving the induction of embryoid body formation...
4.
Witteveldt J, Knol L, Macias S
Elife
. 2019 Apr;
8.
PMID: 31012846
When mammalian cells detect a viral infection, they initiate a type I interferon (IFNs) response as part of their innate immune system. This antiviral mechanism is conserved in virtually all...
5.
Watson S, Knol L, Witteveldt J, Macias S
Noncoding RNA
. 2019 Mar;
5(1).
PMID: 30909383
As part of their innate immune response against viral infections, mammals activate the expression of type I interferons to prevent viral replication and dissemination. An antiviral RNAi-based response can be...
6.
Witteveldt J, Ivens A, Macias S
Cell Rep
. 2018 Jun;
23(11):3275-3285.
PMID: 29898398
Type I interferons (IFNs) are central components of the antiviral response. Most cell types respond to viral infections by secreting IFNs, but the mechanisms that regulate correct expression of these...
7.
Thomson E, Ip C, Badhan A, Christiansen M, Adamson W, Ansari M, et al.
J Clin Microbiol
. 2016 Jul;
54(10):2470-84.
PMID: 27385709
Affordable next-generation sequencing (NGS) technologies for hepatitis C virus (HCV) may potentially identify both viral genotype and resistance genetic motifs in the era of directly acting antiviral (DAA) therapies. This...
8.
Witteveldt J, Martin-Gans M, Simmonds P
Antimicrob Agents Chemother
. 2016 Mar;
60(5):2981-92.
PMID: 26953209
Treatment for hepatitis C virus (HCV) has improved greatly through the use of direct-acting antivirals (DAAs). However, their effectiveness and potential for drug resistance development in non-genotype 1 variants of...
9.
Atkinson N, Witteveldt J, Evans D, Simmonds P
Nucleic Acids Res
. 2014 Jan;
42(7):4527-45.
PMID: 24470146
Most RNA viruses infecting mammals and other vertebrates show profound suppression of CpG and UpA dinucleotide frequencies. To investigate this functionally, mutants of the picornavirus, echovirus 7 (E7), were constructed...
10.
Witteveldt J, Blundell R, Maarleveld J, McFadden N, Evans D, Simmonds P
Nucleic Acids Res
. 2013 Dec;
42(5):3314-29.
PMID: 24335283
RNA viruses infecting vertebrates differ fundamentally in their ability to establish persistent infections with markedly different patterns of transmission, disease mechanisms and evolutionary relationships with their hosts. Although interactions with...