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Steven K H Foung

Explore the profile of Steven K H Foung including associated specialties, affiliations and a list of published articles. Areas
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Articles 69
Citations 2719
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Recent Articles
1.
Mukherji A, Juhling F, Simanjuntak Y, Crouchet E, Del Zompo F, Teraoka Y, et al.
Nat Commun . 2024 Aug; 15(1):7486. PMID: 39209804
Chronic liver disease and cancer are global health challenges. The role of the circadian clock as a regulator of liver physiology and disease is well established in rodents, however, the...
2.
Mah J, Keck M, Chu D, Sooryanarain H, Sahoo M, Lau P, et al.
Vox Sang . 2023 Jun; 118(8):674-680. PMID: 37366233
Background And Objectives: Hepatitis E virus (HEV) is an underrecognized and emerging infectious disease that may threaten the safety of donor blood supply in many parts of the world. We...
3.
Wang R, Suzuki S, Guest J, Heller B, Almeda M, Andrianov A, et al.
Proc Natl Acad Sci U S A . 2022 Mar; 119(11):e2112008119. PMID: 35263223
SignificanceHepatitis C virus chronically infects approximately 1% of the world's population, making an effective vaccine for hepatitis C virus a major unmet public health need. The membrane-associated E1E2 envelope glycoprotein...
4.
Salas J, Urbanowicz R, Guest J, Frumento N, Figueroa A, Clark K, et al.
Gastroenterology . 2021 Oct; 162(2):562-574. PMID: 34655573
Background & Aims: Development of a prophylactic hepatitis C virus (HCV) vaccine will require accurate and reproducible measurement of neutralizing breadth of vaccine-induced antibodies. Currently available HCV panels may not...
5.
Guest J, Wang R, Elkholy K, Chagas A, Chao K, Cleveland 4th T, et al.
Proc Natl Acad Sci U S A . 2021 Jan; 118(3). PMID: 33431677
Hepatitis C virus (HCV) is a major worldwide health burden, and a preventive vaccine is needed for global control or eradication of this virus. A substantial hurdle to an effective...
6.
Shahid S, Gao M, Gallagher D, Pozharski E, Brinson R, Keck Z, et al.
J Mol Biol . 2020 Nov; 433(2):166714. PMID: 33220264
We determined the crystal structure to 1.8 Å resolution of the Fab fragment of an affinity-matured human monoclonal antibody (HC84.26.5D) that recognizes the E2 envelope glycoprotein of hepatitis C virus...
7.
Pierce B, Keck Z, Wang R, Lau P, Garagusi K, Elkholy K, et al.
J Virol . 2020 Sep; 94(22). PMID: 32878891
An effective vaccine for hepatitis C virus (HCV) is a major unmet need, and it requires an antigen that elicits immune responses to key conserved epitopes. Based on structures of...
8.
Tzarum N, Giang E, Kadam R, Chen F, Nagy K, Augestad E, et al.
Sci Adv . 2020 Aug; 6(30):eabb5642. PMID: 32754640
To achieve global elimination of hepatitis C virus (HCV), an effective cross-genotype vaccine is needed. The HCV envelope glycoprotein E2 is the main target for neutralizing antibodies (nAbs), which aid...
9.
Keck Z, Pierce B, Lau P, Lu J, Wang Y, Underwood A, et al.
PLoS Pathog . 2019 May; 15(5):e1007772. PMID: 31100098
Cumulative evidence supports a role for neutralizing antibodies contributing to spontaneous viral clearance during acute hepatitis C virus (HCV) infection. Information on the timing and specificity of the B cell...
10.
Wrensch F, Ligat G, Heydmann L, Schuster C, Zeisel M, Pessaux P, et al.
Hepatology . 2019 May; 70(5):1506-1520. PMID: 31062385
Although adaptive immune responses against hepatitis C virus (HCV) infection have been studied in great detail, the role of innate immunity in protection against HCV infection and immune evasion is...