Allan G N Angus
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Explore the profile of Allan G N Angus including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
383
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Recent Articles
1.
Cowton V, Angus A, Cole S, Markopoulou C, Owsianka A, Dunlop J, et al.
J Virol
. 2016 Jun;
90(16):7456-7468.
PMID: 27279607
Unlabelled: Hepatitis C virus (HCV) enters cells via interactions with several host factors, a key one being that between the viral E2 envelope glycoprotein and the CD81 receptor. We previously...
2.
Keck Z, Angus A, Wang W, Lau P, Wang Y, Gatherer D, et al.
PLoS Pathog
. 2014 Aug;
10(8):e1004297.
PMID: 25122476
A challenge for hepatitis C virus (HCV) vaccine development is to define epitopes that are able to elicit protective antibodies against this highly diverse virus. The E2 glycoprotein region located...
3.
Zhou X, Sun P, Lucendo-Villarin B, Angus A, Szkolnicka D, Cameron K, et al.
Stem Cell Reports
. 2014 Jul;
3(1):204-14.
PMID: 25068132
In this study, human embryonic stem cell-derived hepatocytes (hESC-Heps) were investigated for their ability to support hepatitis C virus (HCV) infection and replication. hESC-Heps were capable of supporting the full...
4.
Di Lorenzo C, Angus A, Patel A
Viruses
. 2011 Dec;
3(11):2280-2300.
PMID: 22163345
Hepatitis C virus (HCV) represents a major public health problem, affecting 3% of the world's population. The majority of infected individuals develop chronic hepatitis, which can progress to cirrhosis and...
5.
Angus A, Loquet A, Stack S, Dalrymple D, Gatherer D, Penin F, et al.
J Virol
. 2011 Nov;
86(2):679-90.
PMID: 22072760
Hepatitis C virus core protein forms the viral nucleocapsid and plays a critical role in the formation of infectious particles. In this study, we demonstrate that the highly conserved residue...
6.
Angus A, Patel A
Future Microbiol
. 2011 Apr;
6(3):279-94.
PMID: 21449840
HCV is a major cause of chronic liver disease worldwide. There is no vaccine available and the current antiviral therapies fail to cure approximately half of treated patients. Liver disease...
7.
Dhillon S, Witteveldt J, Gatherer D, Owsianka A, Zeisel M, Zahid M, et al.
J Virol
. 2010 Mar;
84(11):5494-507.
PMID: 20237087
Cell culture-adaptive mutations within the hepatitis C virus (HCV) E2 glycoprotein have been widely reported. We identify here a single mutation (N415D) in E2 that arose during long-term passaging of...
8.
Angus A, Dalrymple D, Boulant S, McGivern D, Clayton R, Scott M, et al.
J Gen Virol
. 2009 Oct;
91(Pt 1):122-32.
PMID: 19793905
The cellular DEAD-box protein DDX3 was recently shown to be essential for hepatitis C virus (HCV) replication. Prior to that, we had reported that HCV core binds to DDX3 in...
9.
Hughes M, Gretton S, Shelton H, Brown D, McCormick C, Angus A, et al.
J Virol
. 2009 Aug;
83(20):10788-96.
PMID: 19656877
We previously demonstrated that two closely spaced polyproline motifs, with the consensus sequence Pro-X-X-Pro-X-Lys/Arg, located between residues 343 to 356 of NS5A, mediated interactions with cellular SH3 domains. The N-terminal...
10.
Iro M, Witteveldt J, Angus A, Woerz I, Kaul A, Bartenschlager R, et al.
Antiviral Res
. 2009 Apr;
83(2):148-55.
PMID: 19397930
The human pathogen hepatitis C virus (HCV) is associated with chronic liver disease. The recent development of the cell culture infectious HCV (HCVcc) system has opened up avenues for detailed...