Jeremy S Parker
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Explore the profile of Jeremy S Parker including associated specialties, affiliations and a list of published articles.
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21
Citations
428
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Recent Articles
1.
Forshaw S, Parker J, Scott W, Knighton R, Tiwari N, Oladeji S, et al.
Org Biomol Chem
. 2023 Dec;
22(3):590-605.
PMID: 38131271
Biphenyl-fused-dioxacyclodecynes are a promising class of strained alkyne for use in Cu-free 'click' reactions. In this paper, a series of functionalised derivatives of this class of reagent, containing fluorescent groups,...
2.
Dannheim F, Walsh S, Orozco C, Hansen A, Bargh J, Jackson S, et al.
Chem Sci
. 2022 Aug;
13(30):8781-8790.
PMID: 35975158
Antibody-drug conjugates (ADCs) are valuable therapeutic entities which leverage the specificity of antibodies to selectively deliver cytotoxins to antigen-expressing targets such as cancer cells. However, current methods for their construction...
3.
Forshaw S, Knighton R, Reber J, Parker J, Chmel N, Wills M
RSC Adv
. 2022 May;
9(62):36154-36161.
PMID: 35540623
We report the synthesis of a bipyridyl reagent containing a strained alkyne, which significantly restricts its flexibility. Upon strain-promoted alkyne-azide cycloaddition (SPAAC) with an azide, which does not require a...
4.
Seki H, Walsh S, Bargh J, Parker J, Carroll J, Spring D
Chem Sci
. 2021 Jul;
12(26):9060-9068.
PMID: 34276935
Methods for residue-selective and stable modification of canonical amino acids enable the installation of distinct functionality which can aid in the interrogation of biological processes or the generation of new...
5.
Walsh S, Bargh J, Dannheim F, Hanby A, Seki H, Counsell A, et al.
Chem Soc Rev
. 2020 Dec;
50(2):1305-1353.
PMID: 33290462
Antibody-drug conjugates (ADCs) harness the highly specific targeting capabilities of an antibody to deliver a cytotoxic payload to specific cell types. They have garnered widespread interest in drug discovery, particularly...
6.
England R, Moss J, Gunnarsson A, Parker J, Ashford M
Biomacromolecules
. 2020 Jul;
21(8):3332-3341.
PMID: 32672451
This paper describes the synthesis of star polymers designed for future drug-delivery applications. A generation-5 lysine dendrimer was used as a macroinitiator for the ring-opening polymerization of the sarcosine -carboxyanhydride...
7.
Walsh S, Iegre J, Seki H, Bargh J, Sore H, Parker J, et al.
Org Biomol Chem
. 2020 May;
18(22):4224-4230.
PMID: 32432632
Site-selective modification of peptides and proteins has resulted in the development of a host of novel tools for the study of cellular systems or the synthesis of enhanced biotherapeutics. There...
8.
Pettigrew T, Porter R, Walsh S, Housden M, Lam N, Carroll J, et al.
Chem Commun (Camb)
. 2020 Jan;
56(10):1529-1532.
PMID: 31922172
The aplyronines are a family of highly cytotoxic marine natural products with potential application in targeted cancer chemotherapy. To address the severe supply issue, function-oriented molecular editing of their macrolactone...
9.
Macrocyclisation and functionalisation of unprotected peptides via divinyltriazine cysteine stapling
Robertson N, Walsh S, Fowler E, Yoshida M, Rowe S, Wu Y, et al.
Chem Commun (Camb)
. 2019 Jul;
55(64):9499-9502.
PMID: 31328756
We report a novel divinyltriazine linker for the stapling of two cysteine residues to form macrocyclic peptides from their unprotected linear counterparts. The stapling reaction occurred rapidly under mild conditions...
10.
Bargh J, Isidro-Llobet A, Parker J, Spring D
Chem Soc Rev
. 2019 Jul;
48(16):4361-4374.
PMID: 31294429
Antibody-Drug Conjugates (ADCs) are now established as a major class of therapeutics for the clinical treatment of cancer. The properties of the linker between the antibody and the payload are...