Hikaru Seki
Overview
Explore the profile of Hikaru Seki including associated specialties, affiliations and a list of published articles.
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Articles
65
Citations
1713
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Recent Articles
1.
Grimm L, Wijaya A, Askenasy I, Nazeer R, Seki H, Brear P, et al.
J Biol Chem
. 2025 Mar;
:108374.
PMID: 40043953
Pseudomonas aeruginosa is an opportunistic pathogen, commonly associated with human airway infections. Based on its amino acid sequence similarity with Pyrococcus furiosusprotease I, P. aeruginosa PfpI was originally annotated as...
2.
Fujiyama K, Muranaka T, Okazawa A, Seki H, Taguchi G, Yasumoto S
J Biosci Bioeng
. 2024 Apr;
138(1):1-12.
PMID: 38614829
Unable to move on their own, plants have acquired the ability to produce a wide variety of low molecular weight compounds to survive against various stresses. It is estimated that...
3.
Chiyo N, Seki H, Kanamoto T, Ueda H, Kojoma M, Muranaka T
Plant Cell Physiol
. 2023 Dec;
65(2):185-198.
PMID: 38153756
Glycyrrhizin, a type of the triterpenoid saponin, is a major active ingredient contained in the roots of the medicinal plant licorice (Glycyrrhiza uralensis, G. glabra and G. inflata), and is...
4.
Sakanishi M, Chung S, Fujiwara K, Kojoma M, Muranaka T, Seki H
Plant Cell Rep
. 2023 Dec;
43(1):15.
PMID: 38135741
CRISPR-Cas9-mediated disruption of a licorice cellulose synthase-derived glycosyltransferase gene, GuCSyGT, demonstrated the in planta role of GuCSyGT as the enzyme catalyzing 3-O-glucuronosylation of triterpenoid aglycones in soyasaponin biosynthesis. Triterpenoid glycosides...
5.
Sydenham J, Seki H, Krajcovicova S, Zeng L, Schober T, Deingruber T, et al.
Chem Commun (Camb)
. 2023 Dec;
60(6):706-709.
PMID: 38108130
Herein we introduce 3-vinyl-1,2,4-triazines derivatives as dual-reactive linkers that exhibit selectivity towards cysteine and specific strained alkynes, enabling conjugate addition and inverse electron-demand Diels-Alder (IEDDA) reactions. This approach facilitates site-selective...
6.
Istiandari P, Yasumoto S, Seki H, Fukushima E, Muranaka T
Front Plant Sci
. 2023 Aug;
14:1214602.
PMID: 37621889
Cytochrome P450 monooxygenases (CYPs) are enzymes that play critical roles in the structural diversification of triterpenoids. To perform site-specific oxidations of the triterpene scaffold, CYPs require electrons transferred by NADPH-cytochrome...
7.
Takahashi H, Abo C, Suzuki H, Romsuk J, Oi T, Yanagawa A, et al.
New Phytol
. 2023 Jun;
239(3):936-948.
PMID: 37270736
Soybeans (Glycine max) develop newly differentiated aerenchymatous phellem (AP) in response to waterlogging stress. AP is formed in the hypocotyl and root, thus contributing to internal aeration and adaptation to...
8.
Rai A, Hirakawa H, Rai M, Shimizu Y, Shirasawa K, Kikuchi S, et al.
DNA Res
. 2022 Dec;
29(6).
PMID: 36535891
A high-quality genome assembly is imperative to explore the evolutionary basis of characteristic attributes that define chemotype and provide essential resources for a molecular breeding strategy for enhanced production of...
9.
Romsuk J, Yasumoto S, Fukushima E, Miura K, Muranaka T, Seki H
Front Plant Sci
. 2022 Sep;
13:991909.
PMID: 36082301
Oleanolic acid is a pentacyclic triterpenoid found in numerous plant species and is a precursor to several bioactive triterpenoids with commercial potential. However, oleanolic acid accumulates at low levels in...
10.
Romsuk J, Yasumoto S, Seki H, Fukushima E, Muranaka T
Front Bioeng Biotechnol
. 2022 Sep;
10:955650.
PMID: 36061436
Triterpenoids constitute a group of specialized plant metabolites with wide structural diversity and high therapeutic value for human health. Cytochrome P450 monooxygenases (CYP) are a family of enzymes important for...