Jeremy S Duffield
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Explore the profile of Jeremy S Duffield including associated specialties, affiliations and a list of published articles.
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112
Citations
10423
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Recent Articles
1.
Kim Y, Li C, Gu C, Fang Y, Tycksen E, Puri A, et al.
Nat Commun
. 2023 Oct;
14(1):6493.
PMID: 37838725
Misfolded protein aggregates may cause toxic proteinopathy, including autosomal dominant tubulointerstitial kidney disease due to uromodulin mutations (ADTKD-UMOD), a leading hereditary kidney disease. There are no targeted therapies. In our...
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Kim Y, Li C, Gu C, Tycksen E, Puri A, Pietka T, et al.
bioRxiv
. 2023 Jan;
PMID: 36711449
Misfolded protein aggregates may cause toxic proteinopathy, including autosomal dominant tubulointerstitial kidney disease due to uromodulin mutations (ADTKD- ), one of the leading hereditary kidney diseases, and Alzheimer’s disease etc....
4.
Daehn I, Duffield J
Nat Rev Drug Discov
. 2021 Jul;
20(10):770-788.
PMID: 34262140
Loss of normal kidney function affects more than 10% of the population and contributes to morbidity and mortality. Kidney diseases are currently treated with immunosuppressive agents, antihypertensives and diuretics with...
5.
Kim Y, Wang Z, Li C, Kidd K, Wang Y, Johnson B, et al.
Am J Physiol Renal Physiol
. 2021 Jul;
321(2):F236-F244.
PMID: 34251273
Autosomal dominant tubulointerstitial kidney disease (ADTKD)-uromodulin ( is the most common nonpolycystic genetic kidney disease, but it remains unrecognized due to its clinical heterogeneity and lack of screening test. Moreover,...
6.
Baek J, Gomez I, Wada Y, Roach A, Mahad D, Duffield J
Am J Pathol
. 2018 Oct;
188(12):2745-2762.
PMID: 30268775
Mutations in mitochondrial DNA as well as nuclear-encoded mitochondrial proteins have been reported to cause tubulointerstitial kidney diseases and focal segmental glomerulosclerosis (FSGS). Recently, genes and pathways affecting mitochondrial turnover...
7.
Puranik A, Leaf I, Jensen M, Hedayat A, Saad A, Kim K, et al.
Sci Rep
. 2018 Sep;
8(1):13948.
PMID: 30224726
Renal artery stenosis (RAS) caused by narrowing of arteries is characterized by microvascular damage. Macrophages are implicated in repair and injury, but the specific populations responsible for these divergent roles...
8.
Lemos D, McMurdo M, Karaca G, Wilflingseder J, Leaf I, Gupta N, et al.
J Am Soc Nephrol
. 2018 May;
29(6):1690-1705.
PMID: 29739813
Kidney injury is characterized by persisting inflammation and fibrosis, yet mechanisms by which inflammatory signals drive fibrogenesis remain poorly defined. RNA sequencing of fibrotic kidneys from patients with CKD identified...
9.
Lemos D, Duffield J
Sci Transl Med
. 2018 Feb;
10(426).
PMID: 29386358
Recent scientific findings support the notion that fibrosis is driven by tissue-specific cellular and molecular mechanisms. Analysis of seemingly equivalent mesenchymal stromal cell (MSC) populations residing in different organs revealed...
10.
Johnson B, Dang L, Marsh G, Roach A, Levine Z, Monti A, et al.
J Clin Invest
. 2017 Oct;
127(11):3954-3969.
PMID: 28990932
Uromodulin-associated kidney disease (UAKD) is caused by mutations in the uromodulin (UMOD) gene that result in a misfolded form of UMOD protein, which is normally secreted by nephrons. In UAKD...