Jeremy M Beck
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Explore the profile of Jeremy M Beck including associated specialties, affiliations and a list of published articles.
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9
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71
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Recent Articles
1.
Franjesevic A, Sillart S, Beck J, Vyas S, Callam C, Hadad C
Chemistry
. 2018 Nov;
25(21):5337-5371.
PMID: 30444932
Organophosphorus (OP) nerve agents and pesticides present significant threats to civilian and military populations. OP compounds include the nefarious G and V chemical nerve agents, but more commonly, civilians are...
2.
Yoder R, Zhuang Q, Beck J, Franjesevic A, Blanton T, Sillart S, et al.
ACS Med Chem Lett
. 2017 Jun;
8(6):622-627.
PMID: 28626522
Acetylcholinesterase (AChE) is an essential enzyme that can be targeted by organophosphorus (OP) compounds, including nerve agents. Following exposure to OPs, AChE becomes phosphylated (inhibited) and undergoes a subsequent aging...
3.
Beck J, Springer C
J Chem Inf Model
. 2014 Mar;
54(4):1226-34.
PMID: 24605924
The concepts of activity cliffs and matched molecular pairs (MMP) are recent paradigms for analysis of data sets to identify structural changes that may be used to modify the potency...
4.
Sanan T, Muthukrishnan S, Beck J, Tao P, Hayes C, Otto T, et al.
J Phys Org Chem
. 2013 Oct;
23(4):357-369.
PMID: 24077808
The enzyme human paraoxonase 1 (huPON1) has demonstrated significant potential for use as a bioscavenger for treatment of exposure to organophosphorus (OP) nerve agents. Herein we report the development of...
5.
Beck J, Miller S, Peczuh M, Hadad C
J Org Chem
. 2012 Apr;
77(9):4242-51.
PMID: 22493940
A computational investigation into the hydrolysis of two methyl septanosides, methyl-α-D-glycero-D-guloseptanoside and methyl-β-D-glycero-D-guloseptanoside was undertaken. These septanosides were chosen as model compounds for comparison to methyl pyranosides and allowed direct...
6.
Vyas S, Beck J, Xia S, Zhang J, Hadad C
Chem Biol Interact
. 2010 Apr;
187(1-3):241-5.
PMID: 20399202
Butyrylcholinesterase (BuChE) is a stoichiometric bioscavenger against organophosphorus (OP) nerve agent poisoning, and efforts to make BuChE variants that are catalytically active against a wide spectrum of nerve agents have...
7.
Beck J, Hadad C
Chem Biol Interact
. 2010 Feb;
187(1-3):220-4.
PMID: 20156428
The phosphonylation mechanism of AChE and the S203C mutation by sarin (GB) is evaluated using two reaction schemes: a small model nucleophile (ethoxide, CH(3)CH(2)O(-)) and quantum mechanical/molecular mechanical (QM/MM) simulations....
8.
Barakat N, Zheng X, Gilley C, MacDonald M, Okolotowicz K, Cashman J, et al.
Chem Res Toxicol
. 2009 Sep;
22(10):1669-79.
PMID: 19715346
Both G and V type nerve agents possess a center of chirality about phosphorus. The S(p) enantiomers are generally more potent inhibitors than their R(p) counterparts toward acetylcholinesterase (AChE) and...
9.
Beck J, Hadad C
Chem Biol Interact
. 2008 Jun;
175(1-3):200-3.
PMID: 18538754
Density functional theory calculations were employed to study the reaction of five nerve agents with model nucleophiles, including EtX(-) and EtXH (X=O, S, Se) for serine, cysteine and selenocysteine, respectively....