Christopher S Callam
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Explore the profile of Christopher S Callam including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
130
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Recent Articles
1.
Miller K, He Y, Allen S, McElroy C, Callam C, Hadad C
Chem Res Toxicol
. 2025 Mar;
PMID: 40043018
Organophosphorus (OP) compounds pose a serious risk to human health by covalently modifying acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Currently approved oxime therapeutics can reactivate OP-inhibited AChE and BChE, despite significant...
2.
Lovins A, Miller K, Buck A, Ensey D, Homoelle R, Murtha M, et al.
ACS Chem Neurosci
. 2024 Apr;
15(9):1813-1827.
PMID: 38621296
Acetylcholinesterase (AChE) inhibition by organophosphorus (OP) compounds poses a serious health risk to humans. While many therapeutics have been tested for treatment after OP exposure, there is still a need...
3.
Clay W, Buck A, He Y, Hernandez Sanchez D, Ward N, Lear J, et al.
Chem Res Toxicol
. 2024 Apr;
37(4):643-657.
PMID: 38556765
Organophosphorus (OP) nerve agents inhibit acetylcholinesterase (AChE), creating a cholinergic crisis in which death can occur. The phosphylated serine residue spontaneously dealkylates to the OP-aged form, which current therapeutics cannot...
4.
Amoah E, Kulyk D, Callam C, Hadad C, Badu-Tawiah A
Anal Chem
. 2023 Mar;
95(13):5635-5642.
PMID: 36947664
Rare sugars have gained popularity in recent years due to their use in antiaging treatments, their ability to sweeten with few calories, and their ability to heal infections. Rare sugars...
5.
Franjesevic A, Sillart S, Beck J, Vyas S, Callam C, Hadad C
Chemistry
. 2018 Nov;
25(21):5337-5371.
PMID: 30444932
Organophosphorus (OP) nerve agents and pesticides present significant threats to civilian and military populations. OP compounds include the nefarious G and V chemical nerve agents, but more commonly, civilians are...
6.
Zhuang Q, Franjesevic A, Corrigan T, Coldren W, Dicken R, Sillart S, et al.
J Med Chem
. 2018 Jun;
61(16):7034-7042.
PMID: 29870665
After the inhibition of acetylcholinesterase (AChE) by organophosphorus (OP) nerve agents, a dealkylation reaction of the phosphylated serine, referred to as aging, can occur. When aged, known reactivators of OP-inhibited...
7.
Yoder R, Zhuang Q, Beck J, Franjesevic A, Blanton T, Sillart S, et al.
ACS Med Chem Lett
. 2017 Jun;
8(6):622-627.
PMID: 28626522
Acetylcholinesterase (AChE) is an essential enzyme that can be targeted by organophosphorus (OP) compounds, including nerve agents. Following exposure to OPs, AChE becomes phosphylated (inhibited) and undergoes a subsequent aging...
8.
Zhuang Q, Young A, Callam C, McElroy C, Ekici O, Yoder R, et al.
Ann N Y Acad Sci
. 2016 Jun;
1374(1):94-104.
PMID: 27327269
Aging is a dealkylation reaction of organophosphorus (OP)-inhibited acetylcholinesterase (AChE). Despite many studies to date, aged AChE cannot be reactivated directly by traditional pyridinium oximes. This review summarizes strategies that...
9.
Verne G, Price D, Callam C, Zhang B, Peck J, Zhou Q
J Pain
. 2012 Sep;
13(9):901-9.
PMID: 22958874
Unlabelled: Irritable bowel syndrome (IBS) is a common gastrointestinal disorder in which the pathophysiological mechanisms of the pain and hypersensitivity are incompletely understood. IBS patients frequently complain of pain in...
10.
Zhou Q, Price D, Dreher K, Pronold B, Callam C, Sharma J, et al.
J Cell Mol Med
. 2011 Nov;
16(8):1900-15.
PMID: 22050903
Many patients suffer from chronic gastrointestinal diseases characterized by chronic inflammation, increased intestinal permeability and visceral pain in which there is no definitive treatment. Adult stem cells have recently been...