Jeremy L Jenkins
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Explore the profile of Jeremy L Jenkins including associated specialties, affiliations and a list of published articles.
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65
Citations
2126
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Recent Articles
1.
Thomas J, Shelton 4th C, Murphy J, Brittain S, Bray M, Aspesi P, et al.
ACS Chem Biol
. 2024 Apr;
19(4):938-952.
PMID: 38565185
Phenotypic assays have become an established approach to drug discovery. Greater disease relevance is often achieved through cellular models with increased complexity and more detailed readouts, such as gene expression...
2.
Shen L, Fang J, Liu L, Yang F, Jenkins J, Kutchukian P, et al.
J Cheminform
. 2024 Mar;
16(1):33.
PMID: 38515171
We present a user-friendly molecular generative pipeline called Pocket Crafter, specifically designed to facilitate hit finding activity in the drug discovery process. This workflow utilized a three-dimensional (3D) generative modeling...
3.
Godinez W, Trifonov V, Fang B, Kuzu G, Pei L, Guiguemde W, et al.
J Chem Inf Model
. 2024 Jan;
64(7):2695-2704.
PMID: 38293736
Predicting compound activity in assays is a long-standing challenge in drug discovery. Computational models based on compound-induced gene expression signatures from a single profiling assay have shown promise toward predicting...
4.
Li J, Canham S, Wu H, Henault M, Chen L, Liu G, et al.
Nat Chem Biol
. 2023 Oct;
20(3):365-372.
PMID: 37828400
Stimulator of interferon genes (STING) is a dimeric transmembrane adapter protein that plays a key role in the human innate immune response to infection and has been therapeutically exploited for...
5.
Li J, Ho D, Henault M, Yang C, Neri M, Ge R, et al.
ACS Chem Biol
. 2022 May;
17(6):1401-1414.
PMID: 35508359
Unbiased transcriptomic RNA-seq data has provided deep insights into biological processes. However, its impact in drug discovery has been narrow given high costs and low throughput. Proof-of-concept studies with Digital...
6.
Tan C, Ginzberg M, Webster R, Iyengar S, Liu S, Papadopoli D, et al.
Dev Cell
. 2021 May;
56(12):1756-1769.e7.
PMID: 34022133
While molecules that promote the growth of animal cells have been identified, it remains unclear how such signals are orchestrated to determine a characteristic target size for different cell types....
7.
Cho H, Shen Q, Zhang L, Okumura M, Kawakami A, Ambrose J, et al.
Cell Chem Biol
. 2021 Apr;
28(10):1407-1419.e6.
PMID: 33794192
Three limonoid natural products with selective anti-proliferative activity against BRAF(V600E) and NRAS(Q61K)-mutation-dependent melanoma cell lines were identified. Differential transcriptome analysis revealed dependency of compound activity on expression of the mitochondrial...
8.
Ferrero E, Brachat S, Jenkins J, Marc P, Skewes-Cox P, Altshuler R, et al.
PLoS Comput Biol
. 2020 Aug;
16(8):e1008126.
PMID: 32853229
No abstract available.
9.
Canham S, Wang Y, Cornett A, Auld D, Baeschlin D, Patoor M, et al.
Cell Chem Biol
. 2020 Jul;
27(9):1124-1129.
PMID: 32707038
Chemogenetic libraries, collections of well-defined chemical probes, provide tremendous value to biomedical research but require substantial effort to ensure diversity as well as quality of the contents. We have assembled...
10.
Bender A, Jenkins J, Li Q, Adams S, Cannon E, Glen R
Annu Rep Comput Chem
. 2020 May;
2:141-168.
PMID: 32362803
This chapter discusses recent developments in some of the areas that exploit the molecular similarity principle, novel approaches to capture molecular properties by the use of novel descriptors, focuses on...