Jeremy C Mottram
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Explore the profile of Jeremy C Mottram including associated specialties, affiliations and a list of published articles.
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177
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11209
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Recent Articles
11.
Costa T, Goundry A, Morrot A, Grab D, Mottram J, Lima A
Int J Mol Sci
. 2023 Jan;
24(1.
PMID: 36614101
The protozoan causes Human African Trypanosomiasis, also known as sleeping sickness, and penetrates the central nervous system, leading to meningoencephalitis. The Cathepsin L-like cysteine peptidase of has been implicated in...
12.
Burge R, Jameson K, Wilkinson A, Mottram J
Bio Protoc
. 2022 Dec;
12(21).
PMID: 36505023
Ubiquitination is a post-translational modification conserved across eukaryotic species. It contributes to a variety of regulatory pathways, including proteasomal degradation, DNA repair, and cellular differentiation. The ubiquitination of substrate proteins...
13.
Carnielli J, Dave A, Romano A, Forrester S, de Faria P, Monti-Rocha R, et al.
EBioMedicine
. 2022 Dec;
86:104378.
PMID: 36462405
Background: Miltefosine treatment failure in visceral leishmaniasis in Brazil has been associated with deletion of the miltefosine susceptibility locus (MSL) in Leishmania infantum. The MSL comprises four genes, 3'-nucleotidase/nucleases (NUC1...
14.
Geoghegan V, Carnielli J, Jones N, Saldivia M, Antoniou S, Hughes C, et al.
Commun Biol
. 2022 Nov;
5(1):1305.
PMID: 36437406
Kinetochores in the parasite Leishmania and related kinetoplastids appear to be unique amongst eukaryotes and contain protein kinases as core components. Using the kinetochore kinases KKT2, KKT3 and CLK2 as...
15.
Grace C, Carvalho K, Lima M, Costa Silva V, Reis-Cunha J, Brune M, et al.
mBio
. 2022 Oct;
13(6):e0206822.
PMID: 36222512
Visceral leishmaniasis (VL) is a potentially fatal disease caused mainly by Leishmania infantum in South America and Leishmania donovani in Asia and Africa. Disease outcomes have been associated with patient...
16.
Burge R, Mottram J, Wilkinson A
Curr Opin Microbiol
. 2022 Sep;
70:102202.
PMID: 36099676
In eukaryotic cells, reversible attachment of ubiquitin and ubiquitin-like modifiers (Ubls) to specific target proteins is conducted by multicomponent systems whose collective actions control protein fate and cell behaviour in...
17.
Cayla M, Nievas Y, Matthews K, Mottram J
Trends Parasitol
. 2022 Sep;
38(11):950-961.
PMID: 36075845
Trypanosomatid parasitic protozoa are divergent from opisthokont models and have evolved unique mechanisms to regulate their complex life cycles and to adapt to a range of hosts. Understanding how these...
18.
Rath C, Vivarini A, Dos Santos J, Medina J, Saliba A, Mottram J, et al.
Infect Immun
. 2022 Aug;
90(9):e0032422.
PMID: 35993771
The protozoan parasite infects and replicates inside host macrophages due to subversion of the innate host cell response. In the present study, we demonstrate that TLR3 is required for the...
19.
Jones N, Geoghegan V, Moore G, Carnielli J, Newling K, Calderon F, et al.
Nat Commun
. 2022 Jul;
13(1):4071.
PMID: 35831302
Leishmania are unicellular parasites that cause human and animal diseases. Like other kinetoplastids, they possess large transcriptional start regions (TSRs) which are defined by histone variants and histone lysine acetylation....
20.
Geoghegan V, Mottram J, Jones N
Front Cell Infect Microbiol
. 2022 May;
12:894213.
PMID: 35601102
Proximity labelling is a powerful and rapidly developing technology for exploring the interaction space and molecular environment of a protein of interest at the nanometre scale. In proximity labelling, a...