Graham H Coombs
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Explore the profile of Graham H Coombs including associated specialties, affiliations and a list of published articles.
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96
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8246
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Recent Articles
1.
Biddau M, Kumar T, Henrich P, Laine L, Blackburn G, Chokkathukalam A, et al.
Int J Parasitol
. 2021 Mar;
51(6):441-453.
PMID: 33713652
Malaria is still one of the most important global infectious diseases. Emergence of drug resistance and a shortage of new efficient antimalarials continue to hamper a malaria eradication agenda. Malaria...
2.
Westrop G, Wang L, Blackburn G, Zhang T, Zheng L, Watson D, et al.
PLoS One
. 2017 Dec;
12(12):e0189072.
PMID: 29267346
Trichomonas vaginalis and Tritrichomonas foetus are pathogens that parasitise, respectively, human and bovine urogenital tracts causing disease. Using LC-MS, reference metabolomic profiles were obtained for both species and stable isotope...
3.
Proto W, Jones N, Coombs G, Mottram J
Microb Cell
. 2017 Mar;
1(1):9-20.
PMID: 28357206
Autophagy is a lysosome-dependent degradation mechanism that sequesters target cargo into autophagosomal vesicles. The genome contains apparent orthologues of several autophagy-related proteins including an ATG8 family. These ubiquitin-like proteins are...
4.
Grewal J, McLuskey K, Das D, Myburgh E, Wilkes J, Brown E, et al.
J Biol Chem
. 2016 Mar;
291(18):9492-500.
PMID: 26940875
The structure of a C11 peptidase PmC11 from the gut bacterium, Parabacteroides merdae, has recently been determined, enabling the identification and characterization of a C11 orthologue, PNT1, in the parasitic...
5.
McLuskey K, Grewal J, Das D, Godzik A, Lesley S, Deacon A, et al.
J Biol Chem
. 2016 Mar;
291(18):9482-91.
PMID: 26940874
Clan CD cysteine peptidases, a structurally related group of peptidases that include mammalian caspases, exhibit a wide range of important functions, along with a variety of specificities and activation mechanisms....
6.
Klionsky D, Abdelmohsen K, Abe A, Abedin M, Abeliovich H, Arozena A, et al.
Autophagy
. 2016 Jan;
12(1):1-222.
PMID: 26799652
No abstract available.
7.
Westrop G, Williams R, Wang L, Zhang T, Watson D, Silva A, et al.
PLoS One
. 2015 Sep;
10(9):e0136891.
PMID: 26368322
Comparative genomic analyses of Leishmania species have revealed relatively minor heterogeneity amongst recognised housekeeping genes and yet the species cause distinct infections and pathogenesis in their mammalian hosts. To gain...
8.
Cull B, Godinho J, Rodrigues J, Frank B, Schurigt U, Williams R, et al.
Autophagy
. 2014 Dec;
10(12):2143-57.
PMID: 25484087
Autophagy is a central process behind the cellular remodeling that occurs during differentiation of Leishmania, yet the cargo of the protozoan parasite's autophagosome is unknown. We have identified glycosomes, peroxisome-like...
9.
Zhang R, Watson D, Wang L, Westrop G, Coombs G, Zhang T
J Chromatogr A
. 2014 Aug;
1362:168-79.
PMID: 25160959
It has been reported that HILIC column chemistry has a great effect on the number of detected metabolites in LC-HRMS-based untargeted metabolite profiling studies. However, no systematic investigation has been...
10.
Storm J, Sethia S, Blackburn G, Chokkathukalam A, Watson D, Breitling R, et al.
PLoS Pathog
. 2014 Jan;
10(1):e1003876.
PMID: 24453970
Phospoenolpyruvate carboxylase (PEPC) is absent from humans but encoded in the Plasmodium falciparum genome, suggesting that PEPC has a parasite-specific function. To investigate its importance in P. falciparum, we generated...