Jens Zerrahn
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Explore the profile of Jens Zerrahn including associated specialties, affiliations and a list of published articles.
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14
Citations
924
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Recent Articles
1.
Nouailles G, Dorhoi A, Koch M, Zerrahn J, Weiner 3rd J, Fae K, et al.
J Clin Invest
. 2014 Feb;
124(3):1268-82.
PMID: 24509076
Successful host defense against numerous pulmonary infections depends on bacterial clearance by polymorphonuclear leukocytes (PMNs); however, excessive PMN accumulation can result in life-threatening lung injury. Local expression of CXC chemokines...
2.
Liesenfeld O, Parvanova I, Zerrahn J, Han S, Heinrich F, Munoz M, et al.
PLoS One
. 2011 Jun;
6(6):e20568.
PMID: 21698150
Clearance of infection with intracellular pathogens in mice involves interferon-regulated GTPases of the IRG protein family. Experiments with mice genetically deficient in members of this family such as Irgm1(LRG-47), Irgm3(IGTP),...
3.
Al-Zeer M, Al-Younes H, Braun P, Zerrahn J, Meyer T
PLoS One
. 2009 Feb;
4(2):e4588.
PMID: 19242543
Chlamydial infection of the host cell induces Gamma interferon (IFNgamma), a central immunoprotector for humans and mice. The primary defense against Chlamydia infection in the mouse involves the IFNgamma-inducible family...
4.
Papic N, Hunn J, Pawlowski N, Zerrahn J, Howard J
J Biol Chem
. 2008 Sep;
283(46):32143-51.
PMID: 18784077
Irga6, a myristoylated, interferon-inducible member of the immunity-related GTPase family, contributes to disease resistance against Toxoplasma gondii in mice. Accumulation of Irga6 on the T. gondii parasitophorous vacuole membrane is...
5.
Regulatory interactions between IRG resistance GTPases in the cellular response to Toxoplasma gondii
Hunn J, Koenen-Waisman S, Papic N, Schroeder N, Pawlowski N, Lange R, et al.
EMBO J
. 2008 Sep;
27(19):2495-509.
PMID: 18772884
Members of the immunity-related GTPase (IRG) family are interferon-inducible resistance factors against a broad spectrum of intracellular pathogens including Toxoplasma gondii. The molecular mechanisms governing the function and regulation of...
6.
Hocke A, Lampe M, Witzenrath M, Mollenkopf H, Zerrahn J, Schmeck B, et al.
Cytokine
. 2007 Jul;
38(2):61-73.
PMID: 17611121
Interleukin (IL)-15 has critical impact on the homeostasis and activation of natural killer cells, natural killer T cells, gammadeltaT cells, and CD8(+)T cells, and contributes to antimicrobial defenses particularly at...
7.
Rosseau S, Hocke A, Mollenkopf H, Schmeck B, Suttorp N, Kaufmann S, et al.
Immunology
. 2006 Dec;
120(3):380-91.
PMID: 17163962
Pneumonia is the most common cause of death from infectious disease in the western hemisphere. Pathophysiological and protective processes are initiated by pattern recognition of microbial structures. To provide the...
8.
Martens S, Parvanova I, Zerrahn J, Griffiths G, Schell G, Reichmann G, et al.
PLoS Pathog
. 2005 Nov;
1(3):e24.
PMID: 16304607
The p47 GTPases are essential for interferon-gamma-induced cell-autonomous immunity against the protozoan parasite, Toxoplasma gondii, in mice, but the mechanism of resistance is poorly understood. We show that the p47...
9.
Schmeck B, Zahlten J, Moog K, van Laak V, Huber S, Hocke A, et al.
J Biol Chem
. 2004 Oct;
279(51):53241-7.
PMID: 15485852
Streptococcus pneumoniae is the major cause of community-acquired pneumonia and one of the most common causes of death by infectious disease in industrialized countries. Little is known concerning the mechanisms...
10.
Geserick P, Kaiser F, Klemm U, Kaufmann S, Zerrahn J
Int Immunol
. 2004 Sep;
16(10):1535-48.
PMID: 15351786
The regulatory networks governing development and differentiation of hematopoietic cells are incompletely understood. Members of the Schlafen (Slfn) protein family have been implicated in the regulation of cell growth and...