Sven Hammerschmidt
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Explore the profile of Sven Hammerschmidt including associated specialties, affiliations and a list of published articles.
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192
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4308
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Recent Articles
1.
Zierke L, Mourad R, Kohler T, Musken M, Hammerschmidt S
Front Microbiol
. 2025 Feb;
16:1450984.
PMID: 39980691
Introduction: The capsular polysaccharide (CPS) of pathogenic bacteria is a critical virulence factor, often evading phagocytosis by host immune cells, while also interfering with the contact of the pathogen with...
2.
Fatykhova D, Fritsch V, Siebert K, Methling K, Lalk M, Busche T, et al.
Eur Respir J
. 2024 Sep;
64(6).
PMID: 39231629
is the most common causative agent of community-acquired pneumonia worldwide. A key pathogenic mechanism that exacerbates severity of disease is the disruption of the alveolar-capillary barrier. However, the specific virulence...
3.
Fritsch K, Kruger L, Handtke S, Kohler T, Ozhiganova A, Jahn K, et al.
Thromb Haemost
. 2024 Jul;
125(3):243-254.
PMID: 39029905
Background: Platelets prevent extravasation of capillary fluids into the pulmonary interstitial tissue by sealing gaps in inflamed endothelium. This reduces respiratory distress associated with pneumonia. is the leading cause of...
4.
Brendel M, Kohler T, Neufend J, Puppe A, Gisch N, Hammerschmidt S
J Innate Immun
. 2024 Jun;
16(1):370-384.
PMID: 38901409
Introduction: The hydrophilic, polymeric chain of the lipoteichoic acid (LTA) of the Gram-positive pathobiont Streptococcus pneumoniae is covalently linked to the glycosylglycerolipid α-<sc>d</sc>-glucopyranosyl-(1,3)-diacylglycerol by the LTA ligase TacL, leading to...
5.
Alcorlo M, Abdullah M, Steil L, Sotomayor F, Lopez-de Oro L, de Castro S, et al.
PLoS Pathog
. 2024 Jun;
20(6):e1011883.
PMID: 38838057
ATP-binding cassette (ABC) transport systems are crucial for bacteria to ensure sufficient uptake of nutrients that are not produced de novo or improve the energy balance. The cell surface of...
6.
Purwanto D, Khoeri M, Tafroji W, Margaretha Kaligis S, Wilar R, Johnson Kepel B, et al.
Access Microbiol
. 2024 May;
6(3).
PMID: 38725588
We studied the carriage rate, distribution of serotype, and antimicrobial profile of () among patients with acute respiratory tract infections (ARTI) in two primary health centres and a tertiary referral...
7.
Paulikat A, Schwudke D, Hammerschmidt S, Voss F
Front Immunol
. 2024 May;
15:1392316.
PMID: 38711516
remains a significant global threat, with existing vaccines having important limitations such as restricted serotype coverage and high manufacturing costs. Pneumococcal lipoproteins are emerging as promising vaccine candidates due to...
8.
He S, Voss F, Nicolaie M, Brummelman J, van de Garde M, Bijvank E, et al.
J Infect Dis
. 2024 Apr;
230(6):e1299-e1310.
PMID: 38679601
Clinical Trials Registration: Participants were selected from three clinical studies (NTR3462, NTR5405 and NTR3386) conducted in the Netherlands by the National Institute for Public Health and the Environment (RIVM).
9.
Serra S, Iannotti V, Ferrante M, Tofino-Vian M, Baxendale J, Silberberg G, et al.
iScience
. 2024 Apr;
27(4):109583.
PMID: 38632998
Bacterial meningitis, frequently caused by (pneumococcus), represents a substantial global health threat leading to long-term neurological disorders. This study focused on the cholesterol-binding toxin pneumolysin (PLY) released by pneumococci, specifically...
10.
Jennert F, Schaaf D, Nau R, Kohler T, Hammerschmidt S, Hausler D, et al.
J Innate Immun
. 2024 Apr;
PMID: 38569474
Introduction: Streptococcus pneumoniae is the most common cause of bacterial meningitis and meningoencephalitis in humans. The bacterium produces numerous virulence determinants, among them hydrogen peroxide (H2O2) and pneumolysin (Ply), which...