Jens L Hukelmann
Overview
Explore the profile of Jens L Hukelmann including associated specialties, affiliations and a list of published articles.
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10
Citations
1034
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Recent Articles
1.
Ryan D, Knatko E, Casey A, Hukelmann J, Naidu S, Brenes A, et al.
iScience
. 2022 Feb;
25(2):103827.
PMID: 35198887
To overcome oxidative, inflammatory, and metabolic stress, cells have evolved cytoprotective protein networks controlled by nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) and its negative regulator, Kelch-like ECH associated protein...
2.
Brenes A, Yoshikawa H, Bensaddek D, Mirauta B, Seaton D, Hukelmann J, et al.
Cell Rep
. 2021 Apr;
35(4):109032.
PMID: 33910018
X chromosome inactivation (XCI) is a dosage compensation mechanism in female mammals whereby transcription from one X chromosome is repressed. Analysis of human induced pluripotent stem cells (iPSCs) derived from...
3.
Damasio M, Marchingo J, Spinelli L, Hukelmann J, Cantrell D, Howden A
Biochem J
. 2020 Dec;
478(1):79-98.
PMID: 33305809
The integration of multiple signalling pathways that co-ordinate T cell metabolism and transcriptional reprogramming is required to drive T cell differentiation and proliferation. One key T cell signalling module is...
4.
Howden A, Hukelmann J, Brenes A, Spinelli L, Sinclair L, Lamond A, et al.
Nat Immunol
. 2019 Oct;
20(11):1542-1554.
PMID: 31591570
Quantitative mass spectrometry reveals how CD4 and CD8 T cells restructure proteomes in response to antigen and mammalian target of rapamycin complex 1 (mTORC1). Analysis of copy numbers per cell...
5.
Sinclair L, Howden A, Brenes A, Spinelli L, Hukelmann J, Macintyre A, et al.
Elife
. 2019 Mar;
8.
PMID: 30916644
Immune activated T lymphocytes modulate the activity of key metabolic pathways to support the transcriptional reprograming and reshaping of cell proteomes that permits effector T cell differentiation. The present study...
6.
Loftus R, Assmann N, Kedia-Mehta N, OBrien K, Garcia A, Gillespie C, et al.
Nat Commun
. 2018 Jun;
9(1):2341.
PMID: 29904050
Natural killer (NK) cells are lymphocytes with important anti-tumour functions. Cytokine activation of NK cell glycolysis and oxidative phosphorylation (OXPHOS) are essential for robust NK cell responses. However, the mechanisms...
7.
Hukelmann J, Anderson K, Sinclair L, Grzes K, Murillo A, Hawkins P, et al.
Nat Immunol
. 2015 Nov;
17(1):104-12.
PMID: 26551880
We used high-resolution mass spectrometry to map the cytotoxic T lymphocyte (CTL) proteome and the effect of the metabolic checkpoint kinase mTORC1 on CTLs. The CTL proteome was dominated by...
8.
Preston G, Sinclair L, Kaskar A, Hukelmann J, Navarro M, Ferrero I, et al.
EMBO J
. 2015 Jul;
34(15):2008-24.
PMID: 26136212
Myc controls the metabolic reprogramming that supports effector T cell differentiation. The expression of Myc is regulated by the T cell antigen receptor (TCR) and pro-inflammatory cytokines such as interleukin-2...
9.
Navarro M, Goebel J, Hukelmann J, Cantrell D
Mol Cell Proteomics
. 2014 Oct;
13(12):3544-57.
PMID: 25266776
The focus of the present study was to characterize the phosphoproteome of cytotoxic T cells and to explore the role of the serine threonine kinase PKD2 (Protein Kinase D2) in...
10.
Finlay D, Rosenzweig E, Sinclair L, Feijoo-Carnero C, Hukelmann J, Rolf J, et al.
J Exp Med
. 2012 Nov;
209(13):2441-53.
PMID: 23183047
mTORC1 (mammalian target of rapamycin complex 1) controls transcriptional programs that determine CD8+ cytolytic T cell (CTL) fate. In some cell systems, mTORC1 couples phosphatidylinositol-3 kinase (PI3K) and Akt to...