Doreen A Cantrell
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Explore the profile of Doreen A Cantrell including associated specialties, affiliations and a list of published articles.
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73
Citations
5043
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Recent Articles
1.
Sinclair L, Youdale T, Spinelli L, Gakovic M, Langlands A, Pathak S, et al.
Nat Immunol
. 2025 Feb;
26(3):429-443.
PMID: 40016525
Autophagy shapes CD8 T cell fate; yet the timing, triggers and targets of this process are poorly defined. Herein, we show that naive CD8 T cells have high autophagic flux,...
2.
Brenes A, Griesser E, Sinclair L, Davidson L, Prescott A, Singh F, et al.
Elife
. 2024 Nov;
13.
PMID: 39540879
Human induced pluripotent stem cells (hiPSCs) have great potential to be used as alternatives to embryonic stem cells (hESCs) in regenerative medicine and disease modelling. In this study, we characterise...
3.
Long M, Howden A, Keir H, Rollings C, Giam Y, Pembridge T, et al.
Eur Respir J
. 2023 Dec;
63(3).
PMID: 38097207
Background: Neutrophils are important in the pathophysiology of coronavirus disease 2019 (COVID-19), but the molecular changes contributing to altered neutrophil phenotypes following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection...
4.
Brenes A, Lamond A, Cantrell D
Nat Immunol
. 2023 Apr;
24(5):731.
PMID: 37024535
No abstract available.
5.
Ryan E, Sadiku P, Coelho P, Watts E, Zhang A, Howden A, et al.
Am J Respir Crit Care Med
. 2023 Feb;
207(8):998-1011.
PMID: 36724365
Chronic obstructive pulmonary disease (COPD) is a disease characterized by persistent airway inflammation and disordered macrophage function. The extent to which alterations in macrophage bioenergetics contribute to impaired antioxidant responses...
6.
Ventura P, Gakovic M, Fischer B, Spinelli L, Rota G, Pathak S, et al.
EMBO Rep
. 2022 Oct;
23(11):e55399.
PMID: 36194675
Anticancer T cells acquire a dysfunctional state characterized by poor effector function and expression of inhibitory receptors, such as PD-1. Blockade of PD-1 leads to T cell reinvigoration and is...
7.
Barton P, Davenport A, Hukelmann J, Cantrell D, Stinchcombe J, Richard A, et al.
Eur J Immunol
. 2022 Sep;
52(11):1776-1788.
PMID: 36086884
Bach2 codes for a transcriptional regulator exerting major influences on T cell-mediated immune regulation. Effector CTLs derived from in vitro activation of murine CD8 T cells showed increased proliferative and...
8.
Ryan D, Knatko E, Casey A, Hukelmann J, Naidu S, Brenes A, et al.
iScience
. 2022 Feb;
25(2):103827.
PMID: 35198887
To overcome oxidative, inflammatory, and metabolic stress, cells have evolved cytoprotective protein networks controlled by nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) and its negative regulator, Kelch-like ECH associated protein...
9.
Marchingo J, Cantrell D
Cell Mol Immunol
. 2022 Jan;
19(3):303-315.
PMID: 34983947
T cell activation, proliferation, and differentiation into effector and memory states involve massive remodeling of T cell size and molecular content and create a massive increase in demand for energy...
10.
Lisci M, Barton P, Randzavola L, Ma C, Marchingo J, Cantrell D, et al.
Science
. 2021 Oct;
374(6565):eabe9977.
PMID: 34648346
T cell receptor activation of naïve CD8 T lymphocytes initiates their maturation into effector cytotoxic T lymphocytes (CTLs), which can kill cancer and virally infected cells. Although CTLs show an...