Alejandro J Brenes
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Explore the profile of Alejandro J Brenes including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
128
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Recent Articles
1.
Brenes A
J Proteome Res
. 2024 Nov;
23(12):5274-5278.
PMID: 39573822
The coefficient of variation (CV) is a measure that is frequently used to assess data dispersion for mass spectrometry-based proteomics. In the current era of burgeoning technical developments, there has...
2.
Fleming A, Knatko E, Li X, Zoch A, Heckhausen Z, Stransky S, et al.
Genes Dev
. 2024 Nov;
38(21-24):952-964.
PMID: 39562138
The link between DNA methylation and neurodevelopmental disorders is well established. However, how DNA methylation is fine-tuned-ensuring precise gene expression and developmental fidelity-remains poorly understood. PROSER1, a known TET2 interactor,...
3.
Brenes A, Griesser E, Sinclair L, Davidson L, Prescott A, Singh F, et al.
Elife
. 2024 Nov;
13.
PMID: 39540879
Human induced pluripotent stem cells (hiPSCs) have great potential to be used as alternatives to embryonic stem cells (hESCs) in regenerative medicine and disease modelling. In this study, we characterise...
4.
Lloyd A, Martinez-Muriana A, Davis E, Daniels M, Hou P, Mancuso R, et al.
Cell Rep
. 2024 Oct;
43(11):114908.
PMID: 39460937
Using high-resolution quantitative mass spectrometry, we present comprehensive human and mouse microglia proteomic datasets consisting of over 11,000 proteins across six microglia groups. Microglia share a core protein signature of...
5.
Baker C, Bruderer R, Abbott J, Arthur J, Brenes A
J Proteome Res
. 2024 May;
23(6):1926-1936.
PMID: 38691771
Data-independent acquisition has seen breakthroughs that enable comprehensive proteome profiling using short gradients. As the proteome coverage continues to increase, the quality of the data generated becomes much more relevant....
6.
Sollberger G, Brenes A, Warner J, Arthur J, Howden A
Sci Rep
. 2024 Mar;
14(1):5966.
PMID: 38472281
Neutrophils are one of the first responders to infection and are a key component of the innate immune system through their ability to phagocytose and kill invading pathogens, secrete antimicrobial...
7.
Long M, Howden A, Keir H, Rollings C, Giam Y, Pembridge T, et al.
Eur Respir J
. 2023 Dec;
63(3).
PMID: 38097207
Background: Neutrophils are important in the pathophysiology of coronavirus disease 2019 (COVID-19), but the molecular changes contributing to altered neutrophil phenotypes following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection...
8.
Brenes A, Lamond A, Cantrell D
Nat Immunol
. 2023 Apr;
24(5):731.
PMID: 37024535
No abstract available.
9.
Baker C, Phair I, Brenes A, Atrih A, Ryan D, Bruderer R, et al.
STAR Protoc
. 2022 Sep;
3(4):101725.
PMID: 36166358
Here, we describe an optimized protocol to analyze murine bone-marrow-derived macrophages using label-free data-independent acquisition (DIA) proteomics. We provide a complete step-by-step protocol describing sample preparation utilizing the S-Trap approach...
10.
Ryan D, Knatko E, Casey A, Hukelmann J, Naidu S, Brenes A, et al.
iScience
. 2022 Feb;
25(2):103827.
PMID: 35198887
To overcome oxidative, inflammatory, and metabolic stress, cells have evolved cytoprotective protein networks controlled by nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) and its negative regulator, Kelch-like ECH associated protein...