Jens Carlsson
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Explore the profile of Jens Carlsson including associated specialties, affiliations and a list of published articles.
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102
Citations
2146
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Recent Articles
1.
Luttens A, Cabeza de Vaca I, Sparring L, Brea J, Martinez A, Kahlous N, et al.
Nat Comput Sci
. 2025 Mar;
PMID: 40082701
The accelerating growth of make-on-demand chemical libraries provides unprecedented opportunities to identify starting points for drug discovery with virtual screening. However, these multi-billion-scale libraries are challenging to screen, even for...
2.
Luttens A, Vo D, Scaletti E, Wiita E, Almlof I, Wallner O, et al.
Nat Commun
. 2025 Feb;
16(1):1741.
PMID: 39966348
Fragment-based screening can catalyze drug discovery by identifying novel scaffolds, but this approach is limited by the small chemical libraries studied by biophysical experiments and the challenging optimization process. To...
3.
Petracco E, Ferre G, Kabelka I, Ballante F, Carlsson J, Mulry E, et al.
ACS Chem Biol
. 2025 Jan;
20(2):401-411.
PMID: 39836507
Small molecules are essential for investigating the pharmacology of membrane proteins and remain the most common approach for therapeutically targeting them. However, most experimental small molecule screening methods require ligands...
4.
Diaz-Holguin A, Saarinen M, Vo D, Sturchio A, Branzell N, Cabeza de Vaca I, et al.
Sci Adv
. 2024 Aug;
10(32):eadn1524.
PMID: 39110804
Artificial intelligence is revolutionizing protein structure prediction, providing unprecedented opportunities for drug design. To assess the potential impact on ligand discovery, we compared virtual screens using protein structures generated by...
5.
Areias F, Correia C, Rocha A, Teixeira S, Castro M, Brea J, et al.
Molecules
. 2024 Jun;
29(11).
PMID: 38893418
A set of 2-aryl-9-H or methyl-6-morpholinopurine derivatives were synthesized and assayed through radioligand binding tests at human A, A, A, and A adenosine receptor subtypes. Eleven purines showed potent antagonism...
6.
Carlsson J, Luttens A
Curr Opin Struct Biol
. 2024 Jun;
87:102829.
PMID: 38848655
Structure-based virtual screening aims to find molecules forming favorable interactions with a biological macromolecule using computational models of complexes. The recent surge of commercially available chemical space provides the opportunity...
7.
Curnick D, Deaville R, Bortoluzzi J, Cameron L, Carlsson J, Carlsson J, et al.
J Fish Biol
. 2023 Aug;
103(6):1549-1555.
PMID: 37602958
Three Odontaspis ferox (confirmed by mtDNA barcoding) were found in the English Channel and Celtic Sea in 2023 at Lepe, UK (50.7846, -1.3508), Kilmore Quay, Ireland (52.1714, -6.5937), and Lyme...
8.
Suades A, Qureshi A, McComas S, Coincon M, Rudling A, Chatzikyriakidou Y, et al.
Nat Commun
. 2023 Jul;
14(1):4070.
PMID: 37429918
Glucose transporters (GLUTs) are essential for organism-wide glucose homeostasis in mammals, and their dysfunction is associated with numerous diseases, such as diabetes and cancer. Despite structural advances, transport assays using...
9.
Matricon P, Nguyen A, Vo D, Baltos J, Jaiteh M, Luttens A, et al.
Eur J Med Chem
. 2023 Jun;
257:115419.
PMID: 37301076
Development of subtype-selective leads is essential in drug discovery campaigns targeting G protein-coupled receptors (GPCRs). Herein, a structure-based virtual screening approach to rationally design subtype-selective ligands was applied to the...
10.
Stepnicki P, Wosko S, Bartyzel A, Zieba A, Bartuzi D, Szalaj K, et al.
Molecules
. 2023 May;
28(10).
PMID: 37241951
The dopamine D receptor, which belongs to the family of G protein-coupled receptors (GPCR), is an important and well-validated drug target in the field of medicinal chemistry due to its...