Anirudh Ranganathan
Overview
Explore the profile of Anirudh Ranganathan including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
9
Citations
172
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Borroto-Escuela D, Rodriguez D, Romero-Fernandez W, Kapla J, Jaiteh M, Ranganathan A, et al.
Front Pharmacol
. 2018 Sep;
9:829.
PMID: 30214407
The A adenosine (AR) and D dopamine (DR) receptors form oligomers in the cell membrane and allosteric interactions across the AR-DR heteromer represent a target for development of drugs against...
2.
Matricon P, Ranganathan A, Warnick E, Gao Z, Rudling A, Lambertucci C, et al.
Sci Rep
. 2017 Jul;
7(1):6398.
PMID: 28743961
Fragment-based lead discovery is becoming an increasingly popular strategy for drug discovery. Fragment screening identifies weakly binding compounds that require optimization to become high-affinity leads. As design of leads from...
3.
Ranganathan A, Heine P, Rudling A, Pluckthun A, Kummer L, Carlsson J
ACS Chem Biol
. 2016 Dec;
12(3):735-745.
PMID: 28032980
Peptide-recognizing G protein-coupled receptors (GPCRs) are promising therapeutic targets but often resist drug discovery efforts. Determination of crystal structures for peptide-binding GPCRs has provided opportunities to explore structure-based methods in...
4.
Ranganathan A, Stoddart L, Hill S, Carlsson J
J Med Chem
. 2015 Nov;
58(24):9578-90.
PMID: 26592528
Fragment-based lead discovery (FBLD) holds great promise for drug discovery, but applications to G protein-coupled receptors (GPCRs) have been limited by a lack of sensitive screening techniques and scarce structural...
5.
Linder M, Ranganathan A, Brinck T
J Chem Theory Comput
. 2015 Nov;
9(2):1230-9.
PMID: 26588766
We present a structure-based parametrization of the Linear Interaction Energy (LIE) method and show that it allows for the prediction of absolute protein-ligand binding energies. We call the new model...
6.
Rodriguez D, Ranganathan A, Carlsson J
Curr Top Med Chem
. 2015 Jul;
15(24):2484-503.
PMID: 26126906
G protein-coupled receptors (GPCRs) constitute the largest group of human membrane proteins and have received significant attention in drug discovery for their important roles in physiological processes. Drug development for...
7.
Ranganathan A, Dror R, Carlsson J
Biochemistry
. 2014 Oct;
53(46):7283-96.
PMID: 25347607
Achieving a molecular-level understanding of G-protein-coupled receptor (GPCR) activation has been a long-standing goal in biology and could be important for the development of novel drugs. Recent breakthroughs in structural...
8.
Rodriguez D, Ranganathan A, Carlsson J
J Chem Inf Model
. 2014 Jul;
54(7):2004-21.
PMID: 25030302
The recent increase in the number of atomic-resolution structures of G protein-coupled receptors (GPCRs) has contributed to a deeper understanding of ligand binding to several important drug targets. However, reliable...
9.
Chen D, Ranganathan A, IJzerman A, Siegal G, Carlsson J
J Chem Inf Model
. 2013 Aug;
53(10):2701-14.
PMID: 23971943
Fragment-based lead discovery (FBLD) is becoming an increasingly important method in drug development. We have explored the potential to complement NMR-based biophysical screening of chemical libraries with molecular docking in...