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Jenny Wegert

Explore the profile of Jenny Wegert including associated specialties, affiliations and a list of published articles. Areas
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Articles 27
Citations 1240
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Recent Articles
1.
Welter N, Al-Saadi R, Gravier-Dumonceau R, Furtwangler R, Graf N, Wegert J, et al.
Pediatr Blood Cancer . 2025 Feb; 72(4):e31580. PMID: 39895484
Background: Recent research elucidated the prognostic significance of molecular biology in Wilms tumor (WT) by linking somatic genomic variants (such as gain of chromosome 1q) to unfavorable patient outcomes. This...
2.
Perotti D, OSullivan M, Walz A, Davick J, Al-Saadi R, Benedetti D, et al.
Nat Rev Urol . 2025 Jan; PMID: 39881003
Approximately 20% of paediatric and adolescent/young adult patients with renal tumours are diagnosed with non-Wilms tumour, a broad heterogeneous group of tumours that includes clear-cell sarcoma of the kidney, congenital...
3.
Gotz L, Wegert J, Paikari A, Appenzeller S, Bausenwein S, Vokuhl C, et al.
Transl Oncol . 2024 Dec; 52():102263. PMID: 39740515
Wilms tumors (WT) are characterized by variable contributions of blastemal, epithelial and stromal elements, reflecting their diverse cellular origins and genetic drivers. In vitro models remain rare, despite a growing...
4.
Treger T, Wegert J, Wenger A, Coorens T, Al-Saadi R, Kemps P, et al.
Cancer Discov . 2024 Dec; 15(2):286-298. PMID: 39665570
Approximately 10% of children with cancer harbor a mutation in a predisposition gene. In children with the kidney cancer Wilms tumor, the prevalence is as high as 30%. Certain predispositions...
5.
Perotti D, Williams R, Wegert J, Brzezinski J, Maschietto M, Ciceri S, et al.
Nat Rev Urol . 2023 Oct; 21(3):158-180. PMID: 37848532
The modern study of Wilms tumour was prompted nearly 50 years ago, when Alfred Knudson proposed the 'two-hit' model of tumour development. Since then, the efforts of researchers worldwide have...
6.
Wegert J, Fischer A, Palhazi B, Treger T, Hilgers C, Ziegler B, et al.
J Pathol . 2023 Oct; 262(1):10-21. PMID: 37792584
Wilms tumors (WTs) are histologically diverse childhood cancers with variable contributions of blastema, stroma, and epithelia. A variety of cancer genes operate in WTs, including the tripartite-motif-containing-28 gene (TRIM28). Case...
7.
Walz A, Maschietto M, Crompton B, Evageliou N, Dix D, Tytgat G, et al.
Pediatr Blood Cancer . 2023 Jan; 70 Suppl 2:e30130. PMID: 36592003
The expansion of knowledge regarding driver mutations for Wilms tumor (WT) and malignant rhabdoid tumor of the kidney (MRT) and various translocations for other pediatric renal tumors opens up new...
8.
Beck P, Selle B, Madenach L, Jones D, Vokuhl C, Gopisetty A, et al.
iScience . 2022 Apr; 25(4):104167. PMID: 35445187
Pediatric renal cell carcinomas (RCC) differ from their adult counterparts not only in histologic subtypes but also in clinical characteristics and outcome. However, the underlying biology is still largely unclear....
9.
Jimenez Martin O, Schlosser A, Furtwangler R, Wegert J, Gessler M
Cancer Cell Int . 2021 Oct; 21(1):555. PMID: 34689785
Background: Wilms tumor (WT) is the most common renal tumor in childhood. Among others, MYCN copy number gain and MYCN P44L and MAX R60Q mutations have been identified in WT....
10.
Wegert J, Zauter L, Appenzeller S, Otto C, Bausenwein S, Vokuhl C, et al.
Oncogene . 2019 Sep; 39(4):849-861. PMID: 31562394
In vitro models represent a critical tool in cancer research to study tumor biology and to evaluate new treatment options. Unfortunately, there are no effective preclinical models available that represent...