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Jennifer K Thompson

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Articles 27
Citations 1390
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Recent Articles
1.
Healer J, Thompson J, Mackwell K, Browne C, Seager B, Ngo A, et al.
Front Cell Infect Microbiol . 2023 Jan; 12:1049065. PMID: 36605129
Background: RH5 is the leading vaccine candidate for the Plasmodium falciparum blood stage and has shown impact on parasite growth in the blood in a human clinical trial. RH5 binds...
2.
Geoghegan N, Evelyn C, Whitehead L, Pasternak M, McDonald P, Triglia T, et al.
Nat Commun . 2021 Jun; 12(1):3620. PMID: 34131147
Host membrane remodeling is indispensable for viruses, bacteria, and parasites, to subvert the membrane barrier and obtain entry into cells. The malaria parasite Plasmodium spp. induces biophysical and molecular changes...
3.
LaMonte G, Rocamora F, Marapana D, Gnadig N, Ottilie S, Luth M, et al.
Nat Commun . 2020 Apr; 11(1):1780. PMID: 32286267
A promising new compound class for treating human malaria is the imidazolopiperazines (IZP) class. IZP compounds KAF156 (Ganaplacide) and GNF179 are effective against Plasmodium symptomatic asexual blood-stage infections, and are...
4.
Favuzza P, de Lera Ruiz M, Thompson J, Triglia T, Ngo A, Steel R, et al.
Cell Host Microbe . 2020 Feb; 27(4):642-658.e12. PMID: 32109369
Artemisin combination therapy (ACT) is the main treatment option for malaria, which is caused by the intracellular parasite Plasmodium. However, increased resistance to ACT highlights the importance of finding new...
5.
Wilde M, Triglia T, Marapana D, Thompson J, Kouzmitchev A, Bullen H, et al.
mBio . 2019 Oct; 10(5). PMID: 31594816
Understanding the mechanisms behind host cell invasion by remains a major hurdle to developing antimalarial therapeutics that target the asexual cycle and the symptomatic stage of malaria. Host cell entry...
6.
Healer J, Wong W, Thompson J, He W, Birkinshaw R, Miura K, et al.
Cell Microbiol . 2019 Apr; 21(7):e13030. PMID: 30965383
An effective vaccine is a priority for malaria control and elimination. The leading candidate in the Plasmodium falciparum blood stage is PfRh5. PfRh5 assembles into trimeric complex with PfRipr and...
7.
Gilson P, Nguyen W, Poole W, Teixeira J, Thompson J, Guo K, et al.
Antimicrob Agents Chemother . 2018 Dec; 63(3). PMID: 30559138
A series of 4-amino 2-anilinoquinazolines optimized for activity against the most lethal malaria parasite of humans, , was evaluated for activity against other human parasites and related apicomplexans that infect...
8.
Nguyen W, Hodder A, de Lezongard R, Czabotar P, Jarman K, ONeill M, et al.
Eur J Med Chem . 2018 May; 154:182-198. PMID: 29800827
Plasmepsin V is an aspartyl protease that plays a critical role in the export of proteins bearing the Plasmodium export element (PEXEL) motif (RxLxQ/E/D) to the infected host erythrocyte, and...
9.
Laurino M, Leppig K, Abad P, Cham B, Chu Y, Kejriwal S, et al.
J Genet Couns . 2017 Jul; 27(1):21-32. PMID: 28699126
The Professional Society of Genetic Counselors in Asia (PSGCA) was recently established as a special interest group of the Asia Pacific Society of Human Genetics. Fostering partnerships across the globe,...
10.
Laurino M, Sternen D, Thompson J, Leppig K
J Community Genet . 2017 May; 8(3):243-248. PMID: 28547653
The Genetic Counseling Pre-Conference Workshop (GCPCW) was held on September 16, 2015, in Hanoi, Vietnam. We report the GCPCW outcomes obtained from pre- and post-conference questionnaires, case-review breakout session, and...