Wai-Hong Tham
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Explore the profile of Wai-Hong Tham including associated specialties, affiliations and a list of published articles.
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84
Citations
2904
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Recent Articles
1.
D Sa J, Krauss L, Smith L, DAndrea L, Chan L, Abraham A, et al.
J Biol Chem
. 2025 Feb;
301(3):108290.
PMID: 39938801
Plasmodium vivax is emerging as the most prevalent species causing malaria outside Africa. Most P. vivax infections are relapses due to the reactivation of the dormant liver stage parasites (hypnozoites)....
2.
Winnicki A, Dietrich M, Yeoh L, Carias L, Roobsoong W, Drago C, et al.
Nat Commun
. 2024 Dec;
15(1):10556.
PMID: 39632799
New therapeutics are necessary for preventing Plasmodium vivax malaria due to easy transmissibility and dormancy in the liver that increases the clinical burden due to recurrent relapse. In this manuscript...
3.
Dans M, Boulet C, Watson G, Nguyen W, Dziekan J, Evelyn C, et al.
Nat Commun
. 2024 Sep;
15(1):8459.
PMID: 39349462
No abstract available.
4.
Dans M, Boulet C, Watson G, Nguyen W, Dziekan J, Evelyn C, et al.
Nat Commun
. 2024 Jun;
15(1):5219.
PMID: 38890312
With resistance to most antimalarials increasing, it is imperative that new drugs are developed. We previously identified an aryl acetamide compound, MMV006833 (M-833), that inhibited the ring-stage development of newly...
5.
Anstey N, Tham W, Shanks G, Poespoprodjo J, Russell B, Kho S
Trends Parasitol
. 2024 May;
40(7):573-590.
PMID: 38749866
Plasmodium vivax contributes significantly to global malaria morbidity. Key advances include the discovery of pathways facilitating invasion by P. vivax merozoites of nascent reticulocytes, crucial for vaccine development. Humanized mouse...
6.
Adair A, Tan L, Feng J, Girkin J, Bryant N, Wang M, et al.
J Virol
. 2024 May;
98(6):e0053124.
PMID: 38709106
Importance: The pandemic potential presented by coronaviruses has been demonstrated by the ongoing COVID-19 pandemic and previous epidemics caused by severe acute respiratory syndrome coronavirus and Middle East respiratory syndrome...
7.
Nguyen W, Boulet C, Dans M, Loi K, Jarman K, Watson G, et al.
Eur J Med Chem
. 2024 Mar;
270:116354.
PMID: 38554474
Malaria is a devastating disease that causes significant morbidity worldwide. The development of new antimalarial chemotypes is urgently needed because of the emergence of resistance to frontline therapies. Independent phenotypic...
8.
Winnicki A, King C, Bosch J, Malachin A, Carias L, Skomorovska-Prokvolit Y, et al.
bioRxiv
. 2024 Feb;
PMID: 38370683
New therapeutics are necessary for preventing Plasmodium vivax malaria due to easy transmissibility and dormancy in the liver that increases the clinical burden due to recurrent relapse. We isolated 12...
9.
Haycroft E, Davis S, Ramanathan P, Lopez E, Purcell R, Tan L, et al.
Med Microbiol Immunol
. 2023 Jul;
212(4):291-305.
PMID: 37477828
Emerging SARS-CoV-2 variants, notably Omicron, continue to remain a formidable challenge to worldwide public health. The SARS-CoV-2 receptor-binding domain (RBD) is a hotspot for mutations, reflecting its critical role at...
10.
Rudraraju R, Gartner M, Neil J, Stout E, Chen J, Needham E, et al.
Stem Cell Reports
. 2023 Jun;
18(6):1308-1324.
PMID: 37315523
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily infects the respiratory tract, but pulmonary and cardiac complications occur in severe coronavirus disease 2019 (COVID-19). To elucidate molecular mechanisms in the...