Jennie G Pouget
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Explore the profile of Jennie G Pouget including associated specialties, affiliations and a list of published articles.
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30
Citations
978
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Recent Articles
1.
Teymouri K, Ebrahimi M, Chen C, Sriretnakumar V, Mohiuddin A, Tiwari A, et al.
Psychiatry Res
. 2024 Sep;
342:116202.
PMID: 39342786
The complement component 4 (C4) gene, codes for two isotypes, C4A and C4B, and can exist in long or short forms (C4L and C4S). The C4AL variant has been associated...
2.
Fine-mapping the CYP2A6 regional association with nicotine metabolism among African American smokers
Pouget J, Giratallah H, Langlois A, El-Boraie A, Lerman C, Knight J, et al.
Mol Psychiatry
. 2024 Aug;
30(3):943-953.
PMID: 39217253
The nicotine metabolite ratio (NMR; 3'hydroxycotinine/cotinine) is a stable biomarker for CYP2A6 enzyme activity and nicotine clearance, with demonstrated clinical utility in personalizing smoking cessation treatment. Common genetic variation in...
3.
Ebrahimi M, Teymouri K, Chen C, Mohiuddin A, Pouget J, Goncalves V, et al.
Schizophrenia (Heidelb)
. 2024 Feb;
10(1):14.
PMID: 38341430
Schizophrenia is a severe mental illness and a major risk factor for suicide, with approximately 50% of schizophrenia patients attempting and 10% dying from suicide. Although genetic components play a...
4.
Langlois A, Pouget J, Knight J, Chenoweth M, Tyndale R
Eur J Hum Genet
. 2023 Dec;
32(3):357-360.
PMID: 38097766
CYP2A6 is a polymorphic enzyme that inactivates nicotine; structural variants (SVs) include gene deletions and hybrids with the neighboring pseudogene CYP2A7. Two studies found that CYP2A7 deletions were associated with...
5.
Tomasi J, Zai C, Pouget J, Tiwari A, Kennedy J
Psychophysiology
. 2023 Nov;
61(2):e14481.
PMID: 37990619
Establishing quantifiable biological markers associated with anxiety will increase the objectivity of phenotyping and enhance genetic research of anxiety disorders. Heart rate variability (HRV) is a physiological measure reflecting the...
6.
Giratallah H, Chenoweth M, Pouget J, El-Boraie A, Alsaafin A, Lerman C, et al.
Hum Mol Genet
. 2023 Oct;
33(2):198-210.
PMID: 37802914
CYP2A6, a genetically variable enzyme, inactivates nicotine, activates carcinogens, and metabolizes many pharmaceuticals. Variation in CYP2A6 influences smoking behaviors and tobacco-related disease risk. This phenome-wide association study examined associations between...
7.
Langlois A, El-Boraie A, Pouget J, Cox L, Ahluwalia J, Fukunaga K, et al.
J Hum Genet
. 2023 Apr;
68(8):533-541.
PMID: 37059825
CYP2A6 metabolically inactivates nicotine. Faster CYP2A6 activity is associated with heavier smoking and higher lung cancer risk. The CYP2A6 gene is polymorphic, including functional structural variants (SV) such as gene...
8.
Pouget J, Bryushkova L, Koyama E, Zai C, Fonseka T, Mueller D, et al.
Brain Behav
. 2022 Sep;
12(11):e2753.
PMID: 36168941
Background: There is growing evidence that inflammation influences mental health. Blood interleukin levels, which regulate inflammation, have been linked to aggression and internalizing behaviors. We performed a hypothesis-driven genetic study...
9.
Elsheikh S, Muller D, Pouget J
Methods Mol Biol
. 2022 Sep;
2547:389-425.
PMID: 36068471
Antipsychotics are the mainstay treatment for schizophrenia. There is large variability between individuals in their response to antipsychotics, both in efficacy and adverse effects of treatment. While the source of...
10.
El-Boraie A, Chenoweth M, Pouget J, Benowitz N, Fukunaga K, Mushiroda T, et al.
Clin Pharmacol Ther
. 2020 Dec;
110(4):975-985.
PMID: 33300144
The Nicotine Metabolite Ratio (NMR; 3-hydroxycotinine/cotinine), a highly heritable index of nicotine metabolic inactivation by the CYP2A6 enzyme, is associated with numerous smoking behaviors and diseases, as well as unique...