Meghan J Chenoweth
Overview
Explore the profile of Meghan J Chenoweth including associated specialties, affiliations and a list of published articles.
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39
Citations
612
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Recent Articles
1.
Fine-mapping the CYP2A6 regional association with nicotine metabolism among African American smokers
Pouget J, Giratallah H, Langlois A, El-Boraie A, Lerman C, Knight J, et al.
Mol Psychiatry
. 2024 Aug;
30(3):943-953.
PMID: 39217253
The nicotine metabolite ratio (NMR; 3'hydroxycotinine/cotinine) is a stable biomarker for CYP2A6 enzyme activity and nicotine clearance, with demonstrated clinical utility in personalizing smoking cessation treatment. Common genetic variation in...
2.
Langlois A, Chenoweth M, Twesigomwe D, Scantamburlo G, Whirl-Carrillo M, Sangkuhl K, et al.
Clin Pharmacol Ther
. 2024 Jul;
116(4):948-962.
PMID: 39051767
The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the human CYP2A gene locus containing the highly polymorphic CYP2A6 gene. CYP2A6 plays a role in the metabolism of nicotine and various...
3.
Chenoweth M
Neuropsychopharmacology
. 2024 Jun;
49(11):1653-1654.
PMID: 38862577
No abstract available.
4.
Chenoweth M, Kim Y, Nollen N, Hawk Jr L, Mahoney M, Lerman C, et al.
Clin Pharmacol Ther
. 2024 Feb;
115(6):1277-1281.
PMID: 38369951
Varenicline, the most efficacious smoking cessation monotherapy, produces abnormal dreams. Although genetic contributions to varenicline-associated nausea and cessation have been identified, the role of genetics in abnormal dreams is unknown....
5.
Langlois A, Pouget J, Knight J, Chenoweth M, Tyndale R
Eur J Hum Genet
. 2023 Dec;
32(3):357-360.
PMID: 38097766
CYP2A6 is a polymorphic enzyme that inactivates nicotine; structural variants (SVs) include gene deletions and hybrids with the neighboring pseudogene CYP2A7. Two studies found that CYP2A7 deletions were associated with...
6.
Kazi I, Chenoweth M, Jutras-Aswad D, Ahamad K, Socias M, Le Foll B, et al.
Clin Pharmacol Ther
. 2023 Nov;
115(3):506-514.
PMID: 38009933
Methadone and buprenorphine/naloxone are opioid agonist therapies for opioid use disorder treatment. Genetic factors contribute to individual differences in opioid response; however, little is known regarding genetic associations with clinical...
7.
Giratallah H, Chenoweth M, Pouget J, El-Boraie A, Alsaafin A, Lerman C, et al.
Hum Mol Genet
. 2023 Oct;
33(2):198-210.
PMID: 37802914
CYP2A6, a genetically variable enzyme, inactivates nicotine, activates carcinogens, and metabolizes many pharmaceuticals. Variation in CYP2A6 influences smoking behaviors and tobacco-related disease risk. This phenome-wide association study examined associations between...
8.
Langlois A, El-Boraie A, Pouget J, Cox L, Ahluwalia J, Fukunaga K, et al.
J Hum Genet
. 2023 Apr;
68(8):533-541.
PMID: 37059825
CYP2A6 metabolically inactivates nicotine. Faster CYP2A6 activity is associated with heavier smoking and higher lung cancer risk. The CYP2A6 gene is polymorphic, including functional structural variants (SV) such as gene...
9.
Chenoweth M, Lerman C, Knight J, Tyndale R
Nicotine Tob Res
. 2023 Feb;
25(6):1207-1211.
PMID: 36789481
Introduction: Genetic variation in Cytochrome P450 2A6 (CYP2A6), the major nicotine metabolizing enzyme, is associated with nicotine dependence and smoking cessation. Nicotine dependence severity also predicts smoking cessation. Our goals...
10.
Alsaafin A, Chenoweth M, Sylvestre M, OLoughlin J, Tyndale R
Addict Behav
. 2022 Nov;
137:107545.
PMID: 36403489
Background: The endocannabinoid system is implicated in psychiatric disorders and drug dependence. Within this system, fatty acid amide hydrolase (FAAH) metabolizes endocannabinoids. Individuals with A-group genotypes (C/A or A/A) of...