Jeffrey S Stehouwer
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Explore the profile of Jeffrey S Stehouwer including associated specialties, affiliations and a list of published articles.
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24
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134
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Recent Articles
11.
Stehouwer J
Curr Top Med Chem
. 2013 Apr;
13(8):920-35.
PMID: 23590169
The development of tropane-derivatives as cocaine-addiction therapeutics identified numerous compounds with affinities for the dopamine, serotonin, and norepinephrine transporters. Many of these compounds were then adapted for use as imaging...
12.
Nye J, Purselle D, Plisson C, Voll R, Stehouwer J, Votaw J, et al.
Depress Anxiety
. 2013 Mar;
30(10):902-7.
PMID: 23526784
Background: Deficits in serotonergic neurotransmission have been implicated in the pathogenesis of depression and suicidality. The present study utilized a novel positron-emission tomography (PET) ligand to quantitate and compare brain...
13.
Batis J, Barret O, Alagille D, Koren A, Stehouwer J, Cosgrove K, et al.
Nucl Med Biol
. 2012 Oct;
39(8):1137-41.
PMID: 23084043
Introduction: In vivo imaging of the serotonin transporter continues to be a valuable tool in drug development and in monitoring diseases that alter serotonergic function. The purposes of this study...
14.
Sawyer E, Mun J, Nye J, Kimmel H, Voll R, Stehouwer J, et al.
Neuropsychopharmacology
. 2012 Mar;
37(8):1816-24.
PMID: 22434223
Acute SSRI (selective serotonin reuptake inhibitor) treatment has been shown to attenuate the abuse-related effects of cocaine; however, SSRIs have had limited success in clinical trials for cocaine abuse, possibly...
15.
Nicol A, Krishnadas R, Champion S, Tamagnan G, Stehouwer J, Goodman M, et al.
Eur J Nucl Med Mol Imaging
. 2012 Feb;
39(5):786-91.
PMID: 22302090
Purpose: 123I-labelled mZIENT (2β-carbomethoxy-3β-(3′-((Z)-2-iodoethenyl)phenyl)nortropane) has been developed as a radioligand for the serotonin transporter. The aim of this preliminary study was to assess its whole-body biodistribution in humans and estimate...
16.
Stehouwer J, Daniel L, Chen P, Voll R, Williams L, Plott S, et al.
J Med Chem
. 2010 Jul;
53(15):5549-57.
PMID: 20597489
The N-(E)-fluorobutenyl-3beta-(para-halo-phenyl)nortropanes 9-12 were synthesized as ligands of the dopamine transporter (DAT) for use as (18)F-labeled positron emission tomography (PET) imaging agents. In vitro competition binding assays demonstrated that compounds...
17.
Stehouwer J, Goodman M
PET Clin
. 2010 Mar;
4(1):101-28.
PMID: 20216936
This review focuses on the development of fluorine-18 radiolabeled PET tracers for imaging the dopamine transporter (DAT), serotonin transporter (SERT), and norepinephrine transporter (NET). All successful DAT PET tracers reported...
18.
Zeng F, Mun J, Jarkas N, Stehouwer J, Voll R, Tamagnan G, et al.
J Med Chem
. 2008 Dec;
52(1):62-73.
PMID: 19067522
Reboxetine analogues with methyl and fluoroalkyl substituents at position 2 of the phenoxy ring 1-4 were synthesized. In vitro competition binding with [(3)H]nisoxetine demonstrated that 1-4 have a high affinity...
19.
Stehouwer J, Jarkas N, Zeng F, Voll R, Williams L, Camp V, et al.
J Med Chem
. 2008 Dec;
51(24):7788-99.
PMID: 19053782
The meta-vinylhalide fluoroalkyl ester nortropanes 1-4 were synthesized as ligands of the serotonin transporter (SERT) for use as positron emission tomography (PET) imaging agents. In vitro competition binding assays demonstrated...
20.
Zeng F, Jarkas N, Stehouwer J, Voll R, Owens M, Kilts C, et al.
Bioorg Med Chem
. 2007 Nov;
16(2):783-93.
PMID: 17983754
Six new (S,S)-enantiomers of reboxetine derivatives were synthesized and their binding affinities were determined via competition binding assays in cells expressing the human norepinephrine transporter (NET), serotonin transporter (SERT) or...