Jeffrey R Deschamps
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Explore the profile of Jeffrey R Deschamps including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Li F, Kopajtic T, Katz J, Luo D, Prisinzano T, Imler G, et al.
Molecules
. 2022 Dec;
27(24).
PMID: 36557961
The design of enantiopure stereoisomers of N-2-phenylcyclopropylmethyl-substituted ortho-c oxide-bridged phenylmorphans, the E and Z isomers of an N-cinnamyl moiety, and N-propyl enantiomers were based on combining the most potent oxide-bridged...
2.
Mian M, Divovic B, Sharmin D, Pandey K, Golani L, Tiruveedhula V, et al.
ACS Omega
. 2022 Aug;
7(31):27550-27559.
PMID: 35967038
Imidazodiazepine (5-(8-ethynyl-6-(pyridin-2-yl)-4-benzo[]imidazole[1,5-α][1,4]diazepin-3-yl) oxazole or KRM-II-81) is a potentiator of GABA receptors (a GABAkine) undergoing preparation for clinical development. KRM-II-81 is active against many seizure and pain models in rodents, where...
3.
Sulima A, Li F, Morgan J, Truong P, Antoline J, Oertel T, et al.
Molecules
. 2022 Mar;
27(5).
PMID: 35268659
In our continuing effort to develop effective anti-heroin vaccines as potential medications for the treatment of opioid use disorder, herein we present the design and synthesis of the haptens: 1-AmidoMorHap...
4.
Cunningham C, Deschamps J, Coop A
J Pharm Sci Pharmacol
. 2021 Sep;
1(1):54-56.
PMID: 34584903
Opioid analgesics are the treatment of choice for chronic, severe pain. During the course of developing new derivatives of morphine and codeine, we observed an unanticipated S2' substitution reaction product...
5.
Garai S, Leo L, Szczesniak A, Hurst D, Schaffer P, Zagzoog A, et al.
J Med Chem
. 2021 Apr;
64(12):8104-8126.
PMID: 33826336
We apply the magic methyl effect to improve the potency/efficacy of GAT211, the prototypic 2-phenylindole-based cannabinoid type-1 receptor (CB1R) agonist-positive allosteric modulator (ago-PAM). Introducing a methyl group at the α-position...
6.
Gutman E, Bow E, Li F, Sulima A, Kaska S, Crowley R, et al.
RSC Med Chem
. 2021 Jan;
11(8):896-904.
PMID: 33479684
A series of compounds have been synthesized with a variety of substituents based on a three-carbon chain at the C9-position of 3-hydroxy--phenethyl-5-phenylmorphan (3-(2-phenethyl-2-azabicyclo[3.3.1]nonan-5-yl)phenol). Three of these were found to be...
7.
Guerard F, Lee Y, Tripier R, Szajek L, Deschamps J, Brechbiel M
Chem Commun (Camb)
. 2020 Sep;
56(83):12667-12668.
PMID: 32944719
The alternative analysis of A. Bianchi and M. Savastano is a valuable contribution to the understanding of the complex systems at stake in the complexation chemistry of Zr by considering...
8.
Malanoski A, Breger J, Brown C, Deschamps J, Susumu K, Oh E, et al.
Nanoscale Horiz
. 2020 Apr;
2(5):241-252.
PMID: 32260679
Accumulating studies by many groups have found consistent enhancement in a wide variety of enzyme activities when they are displayed around nanoparticles. However, the underlying mechanism(s) that give rise to...
9.
Liu H, Imler G, Baldridge K, OConnor R, Siegel J, Deschamps J, et al.
J Am Chem Soc
. 2020 Jan;
142(6):2755-2759.
PMID: 31986017
Haliclonadiamine and papuamine are bis-indane marine natural products isolated from the marine sponge sp. Their relative structures were previously reported to differ by inversion at only one of their eight...
10.
Slack R, Abramyan A, Tang H, Meena S, Davis B, Bonifazi A, et al.
ACS Chem Neurosci
. 2019 Aug;
10(9):3946-3952.
PMID: 31424193
The serotonin transporter (SERT) is the primary target for the selective serotonin reuptake inhibitors (SSRIs). However, the structural basis for the extraordinarily high binding affinity of the widely prescribed SSRI,...