Jeffrey R Deschamps
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Explore the profile of Jeffrey R Deschamps including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Guo J, Qiu X, Mingoes C, Deschamps J, Susumu K, Medintz I, et al.
ACS Nano
. 2018 Dec;
13(1):505-514.
PMID: 30508369
DNA-nanoparticle conjugates are important tools in nanobiotechnology. Knowing the orientation, function, and length of DNA on nanoparticle surfaces at low nanomolar concentrations under physiological conditions is therefore of great interest....
12.
Garai S, Raja K, Papke R, Deschamps J, Damaj M, Thakur G
ACS Med Chem Lett
. 2018 Nov;
9(11):1144-1148.
PMID: 30429960
We report here the total synthesis of B-973 (five steps), a recently identified α7 nAChR ago-PAM, its enantiomeric resolution, and its electrophysiological characterization in oocytes to identify (-)-B-973B as the...
13.
Lewin A, Brieaddy L, Deschamps J, Imler G, Mascarella S, Anantha Reddy P, et al.
ACS Chem Neurosci
. 2018 Aug;
10(1):246-251.
PMID: 30156829
The demonstrated role of PKC in mediating amphetamine-stimulated dopamine efflux, which regulates amphetamine-induced dopamine transporter trafficking and activity, has promoted the research use of the selective, reversible PKC inhibitor (9...
14.
Vincent C, Giles I, Deschamps J
Acta Crystallogr E Crystallogr Commun
. 2018 May;
74(Pt 3):357-362.
PMID: 29765723
The crystal structure of complexes of 3,4,5-tri-methyl-1-pyrazole with CuCl·2HO and Cu(NO)·2.5HO are presented, namely di-μ-chlorido-bis[chloridobis(3,4,5-trimethyl-1-pyrazole-κ)copper(II)], [CuCl(CHN)] () and aquatetrakis(3,4,5-trimethyl-1-pyrazole-κ)copper(II) dinitrate, [Cu(CHN)(HO)](NO) (), and compared to the previously determined structures for...
15.
Charles P, Wadhwa V, Kouyate A, Mesa-Donado K, Adams A, Deschamps J, et al.
Sensors (Basel)
. 2018 May;
18(5).
PMID: 29762499
Design and evolution of explosives monitoring and detection platforms to address the challenges of trace level chemical identification have led investigations into the use of intricately designed microfluidic devices. Microfluidic...
16.
Ansari M, Healy J, Hom K, Deschamps J, Matsumoto R, Coop A
Org Lett
. 2018 May;
20(10):2984-2987.
PMID: 29737176
During optimization of the synthesis of the mixed μ opioid agonist/δ opioid antagonist 5-(hydroxymethyl)oxymorphone (UMB425) for scale-up, it was unexpectedly discovered that the 4,5-epoxy bridge underwent rearrangement on treatment with...
17.
Nikolayevskiy H, Scerba M, Deschamps J, Appella D
Chemistry
. 2018 Apr;
24(38):9485-9489.
PMID: 29653024
Mercaptobenzamide thioester SAMT-247 is a non-toxic, mutation-resistant HIV-1 maturation inhibitor with a unique mechanism of antiviral activity. NMR spectroscopic analyses of model reactions that mimic the cellular environment answered fundamental...
18.
Hess K, Oh E, Tostanoski L, Andorko J, Susumu K, Deschamps J, et al.
Adv Funct Mater
. 2018 Mar;
27(22).
PMID: 29503604
Treatments for autoimmunity - diseases where the immune system mistakenly attacks self-molecules - are not curative and leave patients immunocompromised. New studies aimed at more specific treatments reveal development of...
19.
Rahman M, Deschamps J, Imler G, Cook J
Chemistry
. 2017 Dec;
24(10):2354-2359.
PMID: 29244896
Extension of the asymmetric Pictet-Spengler reaction to bulkier N -alkylated tryptophan derivatives resulted in an improved stereospecific access to the key bicyclo[3.3.1]nonane core of bioactive C-19 methyl substituted sarpagine/macroline/ajmaline indole...
20.
Sulima A, Jalah R, Antoline J, Torres O, Imler G, Deschamps J, et al.
J Med Chem
. 2017 Dec;
61(1):329-343.
PMID: 29236495
An improved synthesis of a haptenic heroin surrogate 1 (6-AmHap) is reported. The intermediate needed for the preparation of 1 was described in the route in the synthesis of 2...