Jeffrey Mewburn
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Explore the profile of Jeffrey Mewburn including associated specialties, affiliations and a list of published articles.
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19
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558
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Recent Articles
1.
Quin C, DeJong E, Cook E, Luo Y, Vlasschaert C, Sadh S, et al.
J Clin Invest
. 2024 Apr;
134(11).
PMID: 38573824
Individuals with clonal hematopoiesis of indeterminate potential (CHIP) are at increased risk of aging related health conditions and all-cause mortality, but whether CHIP affects risk of infection is much less...
2.
Xiong P, Motamed M, Chen K, Dasgupta A, Potus F, Tian L, et al.
Acta Physiol (Oxf)
. 2022 Jan;
234(2):e13764.
PMID: 34978755
Introduction: Group 2 pulmonary hypertension (PH) has no approved PH-targeted therapy. Metabolic remodelling, specifically a biventricular increase in pyruvate kinase muscle (PKM) isozyme 2 to 1 ratio, occurs in rats...
3.
Dasgupta A, Chen K, Lima P, Mewburn J, Wu D, Al-Qazazi R, et al.
FASEB J
. 2021 Jul;
35(8):e21771.
PMID: 34275172
Impaired mitochondrial fusion, due in part to decreased mitofusin 2 (Mfn2) expression, contributes to unrestricted cell proliferation and apoptosis-resistance in hyperproliferative diseases like pulmonary arterial hypertension (PAH) and non-small cell...
4.
Theilmann A, Hawke L, Hilton L, Whitford M, Cole D, MacKeil J, et al.
Arterioscler Thromb Vasc Biol
. 2020 Oct;
40(11):2605-2618.
PMID: 32998516
Objective: Pulmonary arterial hypertension is a disease of proliferative vascular occlusion that is strongly linked to mutations in -the gene encoding the BMPR-II (BMP [bone morphogenetic protein] type II receptor)....
5.
Michels A, Dwyer C, Mewburn J, Nesbitt K, Kawecki C, Lenting P, et al.
Arterioscler Thromb Vasc Biol
. 2020 Sep;
40(12):2860-2874.
PMID: 32967458
Objective: Obesity is characterized by chronic low-grade inflammation and consequentially a hypercoagulable state, associating with an increased incidence of venous thromboembolism. Increased VWF (von Willebrand factor) plasma concentration and procoagulant...
6.
Tian L, Xiong P, Alizadeh E, Lima P, Potus F, Mewburn J, et al.
Acta Physiol (Oxf)
. 2020 Apr;
229(4):e13483.
PMID: 32339403
Aim: Pulmonary arterial hypertension (PAH) results in right ventricular (RV) dysfunction owing, in part, to RV ischemia. The relative contribution of RV microvascular rarefaction vs reduced right coronary artery perfusion...
7.
Tian L, Wu D, Dasgupta A, Chen K, Mewburn J, Potus F, et al.
Circ Res
. 2020 Mar;
126(12):1723-1745.
PMID: 32216531
Rationale: Right ventricular (RV) fibrosis in pulmonary arterial hypertension contributes to RV failure. While RV fibrosis reflects changes in the function of resident RV fibroblasts (RVfib), these cells are understudied....
8.
Potus F, Pauciulo M, Cook E, Zhu N, Hsieh A, Welch C, et al.
Circulation
. 2020 Mar;
141(24):1986-2000.
PMID: 32192357
Background: Pulmonary arterial hypertension (PAH) is a lethal vasculopathy. Hereditary cases are associated with germline mutations in and 16 other genes; however, these mutations occur in <25% of patients with...
9.
Dasgupta A, Chen K, Wu D, Hoskin V, Mewburn J, Lima P, et al.
FASEB J
. 2020 Feb;
34(4):5106-5127.
PMID: 32068312
Excessive proliferation and apoptosis-resistance are hallmarks of cancer. Increased dynamin-related protein 1 (Drp1)-mediated mitochondrial fission is one of the mediators of this phenotype. Mitochondrial fission that accompanies the nuclear division...
10.
Shida Y, Swystun L, Brown C, Mewburn J, Nesbitt K, Danisment O, et al.
Res Pract Thromb Haemost
. 2019 Apr;
3(2):254-260.
PMID: 31011709
Background: The multimeric glycoprotein von Willebrand factor (VWF) mediates platelet adhesion and aggregation at the site of vessel injury. The adhesive activity of VWF is influenced by its multimer length...