Asish Dasgupta
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Explore the profile of Asish Dasgupta including associated specialties, affiliations and a list of published articles.
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31
Citations
836
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Recent Articles
1.
Wu D, Jansen-van Vuuren R, Dasgupta A, Al-Qazazi R, Chen K, Martin A, et al.
Hypertension
. 2024 Aug;
81(10):2189-2201.
PMID: 39162036
Background: Drp1 (dynamin-related protein 1), a large GTPase, mediates the increased mitochondrial fission, which contributes to hyperproliferation of pulmonary artery smooth muscle cells in pulmonary arterial hypertension (PAH). We developed...
2.
Wu D, Jansen-van Vuuren R, Dasgupta A, Al-Qazazi R, Chen K, Martin A, et al.
bioRxiv
. 2024 Jan;
PMID: 38187628
Rationale: Dynamin-related protein 1 (Drp1), a large GTPase, mediates mitochondrial fission. Increased Drp1-mediated fission permits accelerated mitosis, contributing to hyperproliferation of pulmonary artery smooth muscle cells (PASMC), which characterizes pulmonary...
3.
Wu D, Tian L, Hoskin V, Dasgupta A
Front Cell Dev Biol
. 2023 Nov;
11:1303834.
PMID: 37928899
No abstract available.
4.
Colpman P, Dasgupta A, Archer S
Cells
. 2023 Jul;
12(14).
PMID: 37508561
Mitochondria, which generate ATP through aerobic respiration, also have important noncanonical functions. Mitochondria are dynamic organelles, that engage in fission (division), fusion (joining) and translocation. They also regulate intracellular calcium...
5.
Breault N, Wu D, Dasgupta A, Chen K, Archer S
Front Cell Dev Biol
. 2023 Feb;
11:1105565.
PMID: 36819102
Pulmonary arterial hypertension (PAH) is an orphan disease of the cardiopulmonary unit that reflects an obstructive pulmonary vasculopathy and presents with hypertrophy, inflammation, fibrosis, and ultimately failure of the right...
6.
Archer S, Dasgupta A, Chen K, Wu D, Baid K, Mamatis J, et al.
Redox Biol
. 2022 Nov;
58:102508.
PMID: 36334378
Rationale: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19 pneumonia. We hypothesize that SARS-CoV-2 causes alveolar injury and hypoxemia by damaging mitochondria in airway epithelial cells (AEC) and pulmonary...
7.
Al-Qazazi R, Lima P, Prisco S, Potus F, Dasgupta A, Chen K, et al.
Am J Respir Crit Care Med
. 2022 Jun;
206(5):608-624.
PMID: 35699679
Pulmonary arterial hypertension (PAH) often results in death from right ventricular failure (RVF). NLRP3 (nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3)-macrophage activation may promote RVF in PAH. Evaluating the contribution of...
8.
Xiong P, Motamed M, Chen K, Dasgupta A, Potus F, Tian L, et al.
Acta Physiol (Oxf)
. 2022 Jan;
234(2):e13764.
PMID: 34978755
Introduction: Group 2 pulmonary hypertension (PH) has no approved PH-targeted therapy. Metabolic remodelling, specifically a biventricular increase in pyruvate kinase muscle (PKM) isozyme 2 to 1 ratio, occurs in rats...
9.
Dasgupta A, Chen K, Lima P, Mewburn J, Wu D, Al-Qazazi R, et al.
FASEB J
. 2021 Jul;
35(8):e21771.
PMID: 34275172
Impaired mitochondrial fusion, due in part to decreased mitofusin 2 (Mfn2) expression, contributes to unrestricted cell proliferation and apoptosis-resistance in hyperproliferative diseases like pulmonary arterial hypertension (PAH) and non-small cell...
10.
Wu D, Dasgupta A, Read A, Bentley R, Motamed M, Chen K, et al.
Free Radic Biol Med
. 2021 Jan;
170:150-178.
PMID: 33450375
The homeostatic oxygen sensing system (HOSS) optimizes systemic oxygen delivery. Specialized tissues utilize a conserved mitochondrial sensor, often involving NDUFS2 in complex I of the mitochondrial electron transport chain, as...