Jeffrey L Gustafson
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Explore the profile of Jeffrey L Gustafson including associated specialties, affiliations and a list of published articles.
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31
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1233
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Recent Articles
1.
Shikwana F, Heydari B, Ofori S, Truong C, Turmon A, Darrouj J, et al.
Mol Cell Proteomics
. 2024 Dec;
:100898.
PMID: 39706478
Cysteine chemoproteomic screening platforms are widely utilized for chemical probe and drug discovery campaigns. Chemoproteomic compound screens, which use a mass spectrometry-based proteomic readout, can interrogate the structure activity relationship...
2.
Steen E, Basilaia M, Kim W, Getz T, Gustafson J, Zage P
Biochem Pharmacol
. 2023 Aug;
216:115751.
PMID: 37595672
The RET (REarranged during Transfection) gene, which encodes for a transmembrane receptor tyrosine kinase, is an established oncogene associated with the etiology and progression of multiple types of cancer. Oncogenic...
3.
Toenjes S, Heydari B, Albright S, Hazin R, Ortiz M, Piedrafita F, et al.
ACS Med Chem Lett
. 2023 Mar;
14(3):305-311.
PMID: 36923918
Ibrutinib is a covalent BTK inhibitor that is approved for several indications in oncology. Ibrutinib possesses significant off-target activities toward many kinases, often leading to adverse events in patients. While...
4.
Basilaia M, Chen M, Secka J, Gustafson J
Acc Chem Res
. 2022 Sep;
55(20):2904-2919.
PMID: 36153960
Atropisomerism is a conformational chirality that occurs when there is hindered rotation about a σ-bond. While atropisomerism is exemplified by biaryls, it is observed in many other pharmaceutically relevant scaffolds...
5.
Vaidya S, Heydari B, Toenjes S, Gustafson J
J Org Chem
. 2022 Apr;
87(10):6760-6768.
PMID: 35486501
Diarylamines possess two potentially atropisomeric C-N axes; however, there are few examples of atropisomerically stable diarylamines in the literature, as the contiguous axes can allow for low energy racemization pathways...
6.
Cardenas M, Saputra M, Gordon D, Sanchez A, Yamamoto N, Gustafson J
Chem Commun (Camb)
. 2021 Sep;
57(78):10087-10090.
PMID: 34515276
Herein we report the catalytic atroposelective syntheses of pharmaceutically relevant 3-arylquinolines the nucleophilic aromatic substitution (SAr) of thiophenols into 3-aryl-2-fluoroquinolines mediated by catalytic amounts of Cinchona alkaloid-derived ureas. These reactions...
7.
Toenjes S, Basilaia M, Gustafson J
Future Med Chem
. 2021 Jan;
13(5):443-446.
PMID: 33472413
No abstract available.
8.
Dinh A, Maddox S, Vaidya S, Saputra M, Nalbandian C, Gustafson J
J Org Chem
. 2020 Oct;
85(21):13895-13905.
PMID: 33044067
We report a highly efficient ortho-selective electrophilic chlorination of phenols utilizing a Lewis basic selenoether catalyst. The selenoether catalyst resulted in comparable selectivities to our previously reported bis-thiourea ortho-selective catalyst,...
9.
Choi H, Baek K, Toenjes S, Gustafson J, Smith D
J Am Chem Soc
. 2020 Sep;
142(41):17271-17276.
PMID: 32981317
A new strategy to create highly redox-responsive H-bond dimers based on proton-coupled electron transfer is proposed that capitalizes on the importance of secondary H-bonds in determining overall binding strength in...
10.
Ortiz M, Michaels H, Molina B, Toenjes S, Davis J, Marconi G, et al.
Bioorg Med Chem Lett
. 2020 Mar;
30(9):127108.
PMID: 32192797
Lemur tyrosine kinase 3 (LMTK3) is oncogenic in various cancers. In breast cancer, LMTK3 phosphorylates and modulates the activity of estrogen receptor-α (ERα) and is essential for the growth of...