Jeffrey Kiefer
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Explore the profile of Jeffrey Kiefer including associated specialties, affiliations and a list of published articles.
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15
Citations
454
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Recent Articles
1.
Boudreau M, Duraki D, Wang L, Mao C, Kim J, Henn M, et al.
Sci Transl Med
. 2021 Jul;
13(603).
PMID: 34290053
Metastatic estrogen receptor α (ERα)-positive breast cancer is presently incurable. Seeking to target these drug-resistant cancers, we report the discovery of a compound, called ErSO, that activates the anticipatory unfolded...
2.
Berens M, Sood A, Barnholtz-Sloan J, Graf J, Cho S, Kim S, et al.
PLoS One
. 2019 Dec;
14(12):e0219724.
PMID: 31881020
Glioma is recognized to be a highly heterogeneous CNS malignancy, whose diverse cellular composition and cellular interactions have not been well characterized. To gain new clinical- and biological-insights into the...
3.
Hendricks W, Zismann V, Sivaprakasam K, Legendre C, Poorman K, Tembe W, et al.
PLoS Genet
. 2018 Sep;
14(9):e1007589.
PMID: 30188888
Canine malignant melanoma, a significant cause of mortality in domestic dogs, is a powerful comparative model for human melanoma, but little is known about its genetic etiology. We mapped the...
4.
Network Rewiring in Cancer: Applications to Melanoma Cell Lines and the Cancer Genome Atlas Patients
Ding K, Finlay D, Yin H, Hendricks W, Sereduk C, Kiefer J, et al.
Front Genet
. 2018 Jul;
9:228.
PMID: 30042785
Genes do not work in isolation, but rather as part of networks that have many feedback and redundancy mechanisms. Studying the properties of genetic networks and how individual genes contribute...
5.
Lang J, Hendricks W, Orlando K, Yin H, Kiefer J, Ramos P, et al.
Clin Cancer Res
. 2018 Feb;
24(8):1932-1943.
PMID: 29440177
Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare, aggressive ovarian cancer in young women that is universally driven by loss of the SWI/SNF ATPase subunits SMARCA4...
6.
Ding K, Petricoin E, Finlay D, Yin H, Hendricks W, Sereduk C, et al.
Oncotarget
. 2018 Feb;
9(4):5044-5057.
PMID: 29435161
Cancer cell lines are often used in high throughput drug screens (HTS) to explore the relationship between cell line characteristics and responsiveness to different therapies. Many current analysis methods infer...
7.
Liang W, Hendricks W, Kiefer J, Schmidt J, Sekar S, Carpten J, et al.
Genome Res
. 2017 Apr;
27(4):524-532.
PMID: 28373299
Genomic analyses of cutaneous melanoma (CM) have yielded biological and therapeutic insights, but understanding of non-ultraviolet (UV)-derived CMs remains limited. Deeper analysis of acral lentiginous melanoma (ALM), a rare sun-shielded...
8.
Ding K, Finlay D, Yin H, Hendricks W, Sereduk C, Kiefer J, et al.
Oncotarget
. 2017 Feb;
8(17):27786-27799.
PMID: 28212541
High-throughput screening (HTS) strategies and protocols have undergone significant development in the last decade. It is now possible to screen hundreds of thousands of compounds, each exploring multiple biological phenotypes...
9.
Peng S, Dhruv H, Armstrong B, Salhia B, Legendre C, Kiefer J, et al.
Neuro Oncol
. 2016 Dec;
19(6):833-844.
PMID: 27932423
Background: To elucidate molecular features associated with disproportionate survival of glioblastoma (GB) patients, we conducted deep genomic comparative analysis of a cohort of patients receiving standard therapy (surgery plus concurrent...
10.
Ramos P, Karnezis A, Craig D, Sekulic A, Russell M, Hendricks W, et al.
Nat Genet
. 2014 Mar;
46(5):427-9.
PMID: 24658001
Small cell carcinoma of the ovary of hypercalcemic type (SCCOHT) is an extremely rare, aggressive cancer affecting children and young women. We identified germline and somatic inactivating mutations in the...