Nicholas J Schork
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Explore the profile of Nicholas J Schork including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
McGrouther C, Rangan A, Di Florio A, Elman J, Schork N, Kelsoe J
PLoS One
. 2025 Jan;
20(1):e0314288.
PMID: 39879180
Background: Bipolar Disorder (BD) is a complex disease. It is heterogeneous, both at the phenotypic and genetic level, although the extent and impact of this heterogeneity is not fully understood....
2.
Bailey R, MacFarlane A, Field M, Tagkopoulos I, Baranzini S, Edwards K, et al.
PNAS Nexus
. 2024 Dec;
3(12):pgae461.
PMID: 39677367
Science-informed decisions are best guided by the objective synthesis of the totality of evidence around a particular question and assessing its trustworthiness through systematic processes. However, there are major barriers...
3.
Gladyshev V, Anderson B, Barlit H, Barre B, Beck S, Behrouz B, et al.
PNAS Nexus
. 2024 Dec;
3(12):pgae499.
PMID: 39660064
To gain insight into how researchers of aging perceive the process they study, we conducted a survey among experts in the field. While highlighting some common features of aging, the...
4.
Borrelia PeptideAtlas: A proteome resource of common Borrelia burgdorferi isolates for Lyme research
Reddy P, Sun Z, Wippel H, Baxter D, Swearingen K, Shteynberg D, et al.
Sci Data
. 2024 Dec;
11(1):1313.
PMID: 39622905
Lyme disease is caused by an infection with the spirochete Borrelia burgdorferi, and is the most common vector-borne disease in North America. B. burgdorferi isolates harbor extensive genomic and proteomic...
5.
Zhou H, Lin W, Labra S, Lipton S, Elman J, Schork N, et al.
IEEE/ACM Trans Comput Biol Bioinform
. 2024 Oct;
PP.
PMID: 39471117
Many traditional methods for analyzing gene-gene relationships focus on positive and negative correlations, both of which are a kind of 'symmetric' relationship. Biclustering is one such technique that typically searches...
6.
7.
Trudler D, Ghatak S, Bula M, Parker J, Talantova M, Luevanos M, et al.
Mol Psychiatry
. 2024 Sep;
PMID: 39349966
MEF2C is a critical transcription factor in neurodevelopment, whose loss-of-function mutation in humans results in MEF2C haploinsufficiency syndrome (MHS), a severe form of autism spectrum disorder (ASD)/intellectual disability (ID). Despite...
8.
Yoo D, Rhie A, Hebbar P, Antonacci F, Logsdon G, Solar S, et al.
bioRxiv
. 2024 Aug;
PMID: 39131277
We present haplotype-resolved reference genomes and comparative analyses of six ape species, namely: chimpanzee, bonobo, gorilla, Bornean orangutan, Sumatran orangutan, and siamang. We achieve chromosome-level contiguity with unparalleled sequence accuracy...
9.
Elman J, Schork N, Rangan A
J Alzheimers Dis
. 2024 Jul;
100(4):1209-1226.
PMID: 38995775
Background: Alzheimer's disease (AD) exhibits considerable phenotypic heterogeneity, suggesting the potential existence of subtypes. AD is under substantial genetic influence, thus identifying systematic variation in genetic risk may provide insights...
10.
Ghatak S, Diedrich J, Talantova M, Bhadra N, Scott H, Sharma M, et al.
Adv Sci (Weinh)
. 2024 May;
11(29):e2400545.
PMID: 38773714
Standard single-cell (sc) proteomics of disease states inferred from multicellular organs or organoids cannot currently be related to single-cell physiology. Here, a scPatch-Clamp/Proteomics platform is developed on single neurons generated...